| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1E | PER2 | Ser480 | PVPHSGSsGYGSLGS | phosphorylation down-regulates quantity by destabilization | 30425162 | SIGNOR-277419 |
| CSNK1D | PER2 | Ser480 | PVPHSGSsGYGSLGS | phosphorylation down-regulates quantity by destabilization | 30425162 | SIGNOR-277420 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1E | phosphorylation up-regulates → | PER2 PSer480 | phosphorylation down-regulates ⊣ | PER2 | 30425162 | SIGNOR-277419 |
| CSNK1D | phosphorylation up-regulates → | PER2 PSer480 | phosphorylation down-regulates ⊣ | PER2 | 30425162 | SIGNOR-277420 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1E | phosphorylation![]() down-regulates quantity by destabilization | PER2 | SIGNOR-277419 |
| CSNK1D | phosphorylation![]() down-regulates quantity by destabilization | PER2 | SIGNOR-277420 |