| Name | MAPK13 |
| ID | O15264 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 25-308 PROSITE-ProRule |
View in ![]() |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK13 | EEF2K | Ser359 | GTEEKCGsPQVRTLS | phosphorylation down-regulates | 18337751 | SIGNOR-177986 |
| MAPK13 | EEF2K | Ser359 | GTEEKCGsPQVRTLS | phosphorylation down-regulates activity | 11500363 | SIGNOR-109703 |
| MAPK13 | EEF2K | Ser396 | TFDSLPSsPSSATPH | phosphorylation down-regulates activity | 11500363 | SIGNOR-250089 |
| MAPK13 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates | 10581258 | SIGNOR-72687 |
| MAPK13 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates | 10581258 | SIGNOR-72691 |
| MAPK13 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11788583 | SIGNOR-114075 |
| MAPK13 | MAPT | – | phosphorylation down-regulates activity | 9199504 | SIGNOR-278313 | |
| MAPK13 | STMN1 | Ser25 | QAFELILsPRSKESV | phosphorylation down-regulates | 8125092 | SIGNOR-36362 |
| MAPK13 | STMN1 | Ser25 | QAFELILsPRSKESV | phosphorylation down-regulates | 8325880 | SIGNOR-37848 |
| MAPK13 | STMN1 | Ser38 | SVPEFPLsPPKKKDL | phosphorylation down-regulates | 8325880 | SIGNOR-25826 |
| MAPK13 | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | phosphorylation down-regulates activity | 24703952 | SIGNOR-264449 |
| MAPK13 | PRKD1 | – | phosphorylation down-regulates | 19135240 | SIGNOR-183280 | |
| MAPK13 | RCSD1 | Ser68 | GQNGEEKsPPNASHP | phosphorylation down-regulates activity | 15850461 | SIGNOR-263084 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK13 | phosphorylation up-regulates → | EEF2K PSer359 | phosphorylation down-regulates ⊣ | EEF2K | 18337751 | SIGNOR-177986 |
| MAPK13 | phosphorylation up-regulates → | EEF2K PSer359 | phosphorylation down-regulates ⊣ | EEF2K | 11500363 | SIGNOR-109703 |
| MAPK13 | phosphorylation up-regulates → | EEF2K PSer396 | phosphorylation down-regulates ⊣ | EEF2K | 11500363 | SIGNOR-250089 |
| MAPK13 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 10581258 | SIGNOR-72687 |
| MAPK13 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 10581258 | SIGNOR-72691 |
| MAPK13 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11788583 | SIGNOR-114075 |
| MAPK13 | phosphorylation up-regulates → | STMN1 PSer25 | phosphorylation down-regulates ⊣ | STMN1 | 8125092 | SIGNOR-36362 |
| MAPK13 | phosphorylation up-regulates → | STMN1 PSer25 | phosphorylation down-regulates ⊣ | STMN1 | 8325880 | SIGNOR-37848 |
| MAPK13 | phosphorylation up-regulates → | STMN1 PSer38 | phosphorylation down-regulates ⊣ | STMN1 | 8325880 | SIGNOR-25826 |
| MAPK13 | phosphorylation up-regulates → | TP53BP1 PThr1609 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264449 |
| MAPK13 | phosphorylation up-regulates → | RCSD1 PSer68 | phosphorylation down-regulates ⊣ | RCSD1 | 15850461 | SIGNOR-263084 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK13 | phosphorylation![]() down-regulates | EEF2K | SIGNOR-177986 |
| MAPK13 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-109703 |
| MAPK13 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-250089 |
| MAPK13 | phosphorylation → up-regulates | TP53 | SIGNOR-72687 |
| MAPK13 | phosphorylation → up-regulates | TP53 | SIGNOR-72691 |
| MAPK13 | phosphorylation → up-regulates | KRT8 | SIGNOR-114075 |
| MAPK13 | phosphorylation → down-regulates activity | MAPT | SIGNOR-278313 |
| MAPK13 | phosphorylation![]() down-regulates | STMN1 | SIGNOR-36362 |
| MAPK13 | phosphorylation![]() down-regulates | STMN1 | SIGNOR-37848 |
| MAPK13 | phosphorylation![]() down-regulates | STMN1 | SIGNOR-25826 |
| MAPK13 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264449 |
| MAPK13 | phosphorylation![]() down-regulates | PRKD1 | SIGNOR-183280 |
| MAPK13 | phosphorylation → down-regulates activity | RCSD1 | SIGNOR-263084 |