| + |
MAPK13 | down-regulates 
phosphorylation
|
STMN1 |
0.384 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-37848 |
Ser25 |
QAFELILsPRSKESV |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8325880 |
Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase|The present study shows that the MAP kinase has a 20-fold preference for Ser25 as opposed to Ser38 of Op18, while cdc2 kinases have a 5-fold preference for the Ser38 residue. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-36362 |
Ser25 |
QAFELILsPRSKESV |
Homo sapiens |
T-lymphocyte, Leukemia Cell |
| pmid |
sentence |
| 8125092 |
Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-25826 |
Ser38 |
SVPEFPLsPPKKKDL |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8325880 |
Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
MAPK13 | up-regulates 
phosphorylation
|
TP53 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72687 |
Ser33 |
LPENNVLsPLPSQAM |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 10581258 |
In mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72691 |
Ser46 |
AMDDLMLsPDDIEQW |
Homo sapiens |
|
| pmid |
sentence |
| 10581258 |
In mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK13 | down-regulates
phosphorylation
|
EEF2K |
0.555 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177986 |
Ser359 |
GTEEKCGsPQVRTLS |
Homo sapiens |
|
| pmid |
sentence |
| 18337751 |
The phosphorylation of eef2k at ser359 is of particular interest. First, the phosphorylation of this site strongly decreases the activity of eef2k even at high calcium concentrations (knebel et al, 2001), that is, desensitizes eef2k to the activating effects of elevated ca2+ levels. third, although p38 map kinase (also termed sapk4 can phosphorylate ser359 in vitro (knebel et al, 2001), this enzyme is not known to be active basally or to be regulated by amino acids. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK13 | down-regulates activity
phosphorylation
|
EEF2K |
0.555 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109703 |
Ser359 |
GTEEKCGsPQVRTLS |
Homo sapiens |
|
| pmid |
sentence |
| 11500363 |
Sapk4/p38delta phosphorylated eef2k at ser359 in vitro, causing its inactivation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250089 |
Ser396 |
TFDSLPSsPSSATPH |
in vitro |
|
| pmid |
sentence |
| 11500363 |
eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. eEF2K[S359A] was phosphorylated (presumably at Ser396) by the high concentrations of SAPK4/p38 used in this experiment. However, the inhibition of eEF2K under these conditions was reduced from 82% in the wild-type enzyme to 19% in eEF2K[S359A] |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, In Vitro |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
MAPK13 | down-regulates activity
phosphorylation
|
RCSD1 |
0.437 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263084 |
Ser68 |
GQNGEEKsPPNASHP |
in vitro |
|
| pmid |
sentence |
| 15850461 |
CapZIP was also phosphorylated rapidly by SAPK3/p38γ and SAPK4/p38δ, and even faster and more extensively by JNK1α1, these protein kinases phosphorylating CapZIP in vitro to >3, approx. 2 and >5 mol of phosphate/mol of protein respectively within a few minutes. Following tryptic digestion and C18 chromatography, further sites phosphorylated by JNK1α1 were identified as Ser-68, Ser-83 and Ser-216 (results not shown), and are highlighted in Figure 3.Using this antibody, we showed by immunoblotting that bacterially expressed CapZIP was phosphorylated at Ser-108 by SAPK4/p38δ, JNK1α1 and ERK2 in vitro, as well as by SAPK3/p38γ (results not shown).An important clue to the function of CapZIP and its phosphorylation came from the finding that it binds to the actin-capping protein CapZ (Figure 7A), and that cellular stresses trigger the dissociation of these two proteins (Figure 7B).Such an effect is presumably lost when CapZIP is phosphorylated and dissociates from CapZ. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAPK13 | up-regulates
phosphorylation
|
KRT8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114075 |
Ser74 |
TVNQSLLsPLVLEVD |
Homo sapiens |
|
| pmid |
sentence |
| 11788583 |
Keratin 8 (k8) serine 73 occurs within a relatively conserved type ii keratin motif . Here we show that ser-73 is exclusively phosphorylated in vitro by p38 mitogen-activated protein kinase. The ser-73 --> ala-associated filament reorganization defect is rescued by a ser-73 --> asp mutation. Also, disease-causing keratin mutations can modulate keratin phosphorylation and organization, which may affect disease pathogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK13 | down-regulates activity
phosphorylation
|
TP53BP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264449 |
Thr1609 |
LGPYEAVtPLTKAAD |
in vitro |
|
| pmid |
sentence |
| 24703952 |
Here we show that 53BP1 is phosphorylated during mitosis on two residues, T1609 and S1618, located in its well-conserved ubiquitination-dependent recruitment (UDR) motif.|Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks |phosphorylation of T1609 is likely to be mediated by p38 MAPK |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAP2K6 | up-regulates activity
phosphorylation
|
MAPK13 |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273952 |
Thr180 |
RHADAEMtGYVVTRW |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251424 |
Thr180 |
RHADAEMtGYVVTRW |
in vitro |
|
| pmid |
sentence |
| 9218798 |
SKK3 mediates the activation of SAPK4. Phosphorylation and activation of SAPK4 and SAPK2a by purified SKK3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273951 |
Tyr182 |
ADAEMTGyVVTRWYR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, In Vitro |
| + |
MAP2K7 | up-regulates activity
phosphorylation
|
MAPK13 |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273954 |
Thr180 |
RHADAEMtGYVVTRW |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273953 |
Tyr182 |
ADAEMTGyVVTRWYR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP2K3 | up-regulates activity
phosphorylation
|
MAPK13 |
0.585 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273950 |
Thr180 |
RHADAEMtGYVVTRW |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273949 |
Tyr182 |
ADAEMTGyVVTRWYR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP2K4 | up-regulates activity
phosphorylation
|
MAPK13 |
0.432 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273956 |
Thr180 |
RHADAEMtGYVVTRW |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273955 |
Tyr182 |
ADAEMTGyVVTRWYR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
TRIM27 | up-regulates 
|
MAPK13 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102028 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12807881 |
We found rfp-mediated activation of both exogenous and endogenous forms of the other stress-activated mapk, p38. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK13 | down-regulates
phosphorylation
|
PRKD1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183280 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19135240 |
P38delta catalyzes an inhibitory phosphorylation of pkd1, thereby attenuating stimulated insulin secretion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
(-)-anisomycin | up-regulates
chemical activation
|
MAPK13 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189696 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K6 | up-regulates
phosphorylation
|
MAPK13 |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105698 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11242034 |
Mapkk6 was shown to phosphorylate and specifically activate the p38/mpk2 sub of the mitogen-activated protein kinase superfamily. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42390 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8663074 |
Mapkk6 was shown to phosphorylate and specifically activate the p38/mpk2 sub of the mitogen-activated protein kinase superfamily. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
TNFRSF17 | up-regulates
|
MAPK13 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79501 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10903733 |
Overexpression of bcma activates the p38 mapk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK13 | down-regulates 
|
CDC25B |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-85999 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11333986 |
P38 map k can also induce a g2/m checkpoint through the phosphorylation and the phosphatase cdc25b. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MAPK13
- 
- 