| Name | PPM1D |
| ID | O15297 |
| Role | phosphatase |
| Enzymatic Domains |
PPM-type phosphatase 8-375 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates | 15870257 | SIGNOR-135972 |
| PPM1D | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates activity | 15870257 | SIGNOR-248317 |
| PPM1D | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates activity | 18265945 | SIGNOR-276986 |
| PPM1D | MDM4 | Ser403 | DLAHSSEsQETISSM | dephosphorylation up-regulates quantity by stabilization | 19808970 | SIGNOR-276951 |
| PPM1D | MDM4 | Ser403 | DLAHSSEsQETISSM | dephosphorylation up-regulates quantity by stabilization | 33309518 | SIGNOR-275491 |
| PPM1D | KDM1A | Ser131 | DESLANLsEDEYYSE | dephosphorylation down-regulates activity | 25999347 | SIGNOR-276904 |
| PPM1D | KDM1A | Ser137 | LSEDEYYsEEERNAK | dephosphorylation down-regulates activity | 25999347 | SIGNOR-276905 |
| PPM1D | CHEK2 | Thr68 | SSLETVStQELYSIP | dephosphorylation up-regulates activity | 16311512 | SIGNOR-248318 |
| PPM1D | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates | 15870257 | SIGNOR-135980 |
| PPM1D | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates activity | 15870257 | SIGNOR-248319 |
| PPM1D | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates quantity by destabilization | 18265945 | SIGNOR-276943 |
| PPM1D | GPI | – | dephosphorylation down-regulates activity | 28185954 | SIGNOR-277155 | |
| PPM1D | UNG | – | dephosphorylation down-regulates activity | 15327777 | SIGNOR-277156 | |
| PPM1D | H2AX | Ser140 | GKKATQAsQEY | dephosphorylation down-regulates | 20118229 | SIGNOR-163693 |
| PPM1D | CDKN1B | Ser140 | PKTDPSDsQTGLAEQ | dephosphorylation down-regulates activity | 31959038 | SIGNOR-277109 |
| PPM1D | RPS6KA3 | Ser227 | DHEKKAYsFCGTVEY | dephosphorylation down-regulates activity | 15206906 | SIGNOR-248320 |
| PPM1D | RPS6KA3 | Ser369 | TAKTPKDsPGIPPSA | dephosphorylation down-regulates activity | 15206906 | SIGNOR-248321 |
| PPM1D | RPS6KA3 | Ser386 | HQLFRGFsFVAITSD | dephosphorylation down-regulates activity | 15206906 | SIGNOR-248322 |
| PPM1D | RPS6KA3 | Thr577 | AENGLLMtPCYTANF | dephosphorylation down-regulates activity | 15206906 | SIGNOR-248323 |
| PPM1D | MAPK12 | Thr183 | RQADSEMtGYVVTRW | dephosphorylation down-regulates | 15870257 | SIGNOR-135976 |
| PPM1D | MDM2 | Ser395 | SQESEDYsQPSTSSS | dephosphorylation down-regulates quantity by destabilization | 17936559 | SIGNOR-248324 |
| PPM1D | MDM2 | Ser395 | SQESEDYsQPSTSSS | dephosphorylation up-regulates | 17936559 | SIGNOR-158328 |
| PPM1D | BAX | – | dephosphorylation down-regulates activity | 23907458 | SIGNOR-276993 | |
| PPM1D | TP53BP1 | Thr543 | IDEDGENtQIEDTEP | dephosphorylation down-regulates activity | 31619012 | SIGNOR-277046 |
| PPM1D | ATM | – | dephosphorylation down-regulates | 19360021 | SIGNOR-185135 | |
| PPM1D | ATM | Ser1981 | SLAFEEGsQSTTISS | dephosphorylation down-regulates activity | 16949371 | SIGNOR-248325 |
| PPM1D | ATM | Ser1981 | SLAFEEGsQSTTISS | dephosphorylation down-regulates activity | 18265945 | SIGNOR-276954 |
| PPM1D | ATM | Ser367 | DTRSLEIsQSYTTTQ | dephosphorylation down-regulates activity | 18265945 | SIGNOR-276955 |
| PPM1D | RUNX2 | – | dephosphorylation up-regulates activity | 23907458 | SIGNOR-277110 | |
| PPM1D | MAPK14 | – | dephosphorylation down-regulates activity | 11101524 | SIGNOR-84793 | |
| PPM1D | MAPK14 | – | dephosphorylation down-regulates activity | 19713933 | SIGNOR-187770 | |
| PPM1D | RBM38 | Ser195 | DQYPYAAsPATAASF | dephosphorylation up-regulates activity | 25823026 | SIGNOR-277020 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 15870257 | SIGNOR-135972 |
| PPM1D | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 15870257 | SIGNOR-248317 |
| PPM1D | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 18265945 | SIGNOR-276986 |
| PPM1D | dephosphorylation down-regulates ⊣ | MDM4 PSer403 | dephosphorylation down-regulates ⊣ | MDM4 | 19808970 | SIGNOR-276951 |
| PPM1D | dephosphorylation down-regulates ⊣ | MDM4 PSer403 | dephosphorylation down-regulates ⊣ | MDM4 | 33309518 | SIGNOR-275491 |
| PPM1D | dephosphorylation down-regulates ⊣ | KDM1A PSer131 | dephosphorylation up-regulates → | KDM1A | 25999347 | SIGNOR-276904 |
| PPM1D | dephosphorylation down-regulates ⊣ | KDM1A PSer137 | dephosphorylation up-regulates → | KDM1A | 25999347 | SIGNOR-276905 |
| PPM1D | dephosphorylation down-regulates ⊣ | CHEK2 PThr68 | dephosphorylation down-regulates ⊣ | CHEK2 | 16311512 | SIGNOR-248318 |
| PPM1D | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 15870257 | SIGNOR-135980 |
| PPM1D | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 15870257 | SIGNOR-248319 |
| PPM1D | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 18265945 | SIGNOR-276943 |
| PPM1D | dephosphorylation down-regulates ⊣ | H2AX PSer140 | dephosphorylation up-regulates → | H2AX | 20118229 | SIGNOR-163693 |
| PPM1D | dephosphorylation down-regulates ⊣ | CDKN1B PSer140 | dephosphorylation up-regulates → | CDKN1B | 31959038 | SIGNOR-277109 |
| PPM1D | dephosphorylation down-regulates ⊣ | RPS6KA3 PSer227 | dephosphorylation up-regulates → | RPS6KA3 | 15206906 | SIGNOR-248320 |
| PPM1D | dephosphorylation down-regulates ⊣ | RPS6KA3 PSer369 | dephosphorylation up-regulates → | RPS6KA3 | 15206906 | SIGNOR-248321 |
| PPM1D | dephosphorylation down-regulates ⊣ | RPS6KA3 PSer386 | dephosphorylation up-regulates → | RPS6KA3 | 15206906 | SIGNOR-248322 |
| PPM1D | dephosphorylation down-regulates ⊣ | RPS6KA3 PThr577 | dephosphorylation up-regulates → | RPS6KA3 | 15206906 | SIGNOR-248323 |
| PPM1D | dephosphorylation down-regulates ⊣ | MAPK12 PThr183 | dephosphorylation up-regulates → | MAPK12 | 15870257 | SIGNOR-135976 |
| PPM1D | dephosphorylation down-regulates ⊣ | MDM2 PSer395 | dephosphorylation up-regulates → | MDM2 | 17936559 | SIGNOR-248324 |
| PPM1D | dephosphorylation down-regulates ⊣ | MDM2 PSer395 | dephosphorylation down-regulates ⊣ | MDM2 | 17936559 | SIGNOR-158328 |
| PPM1D | dephosphorylation down-regulates ⊣ | TP53BP1 PThr543 | dephosphorylation up-regulates → | TP53BP1 | 31619012 | SIGNOR-277046 |
| PPM1D | dephosphorylation down-regulates ⊣ | ATM PSer1981 | dephosphorylation up-regulates → | ATM | 16949371 | SIGNOR-248325 |
| PPM1D | dephosphorylation down-regulates ⊣ | ATM PSer1981 | dephosphorylation up-regulates → | ATM | 18265945 | SIGNOR-276954 |
| PPM1D | dephosphorylation down-regulates ⊣ | ATM PSer367 | dephosphorylation up-regulates → | ATM | 18265945 | SIGNOR-276955 |
| PPM1D | dephosphorylation down-regulates ⊣ | RBM38 PSer195 | dephosphorylation down-regulates ⊣ | RBM38 | 25823026 | SIGNOR-277020 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1D | dephosphorylation down-regulates | CHEK1 | SIGNOR-135972 |
| PPM1D | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-248317 |
| PPM1D | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-276986 |
| PPM1D | dephosphorylation → up-regulates quantity by stabilization | MDM4 | SIGNOR-276951 |
| PPM1D | dephosphorylation → up-regulates quantity by stabilization | MDM4 | SIGNOR-275491 |
| PPM1D | dephosphorylation → down-regulates activity | KDM1A | SIGNOR-276904 |
| PPM1D | dephosphorylation → down-regulates activity | KDM1A | SIGNOR-276905 |
| PPM1D | dephosphorylation → up-regulates activity | CHEK2 | SIGNOR-248318 |
| PPM1D | dephosphorylation down-regulates | TP53 | SIGNOR-135980 |
| PPM1D | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248319 |
| PPM1D | dephosphorylation down-regulates quantity by destabilization | TP53 | SIGNOR-276943 |
| PPM1D | dephosphorylation → down-regulates activity | GPI | SIGNOR-277155 |
| PPM1D | dephosphorylation → down-regulates activity | UNG | SIGNOR-277156 |
| PPM1D | dephosphorylation down-regulates | H2AX | SIGNOR-163693 |
| PPM1D | dephosphorylation → down-regulates activity | CDKN1B | SIGNOR-277109 |
| PPM1D | dephosphorylation → down-regulates activity | RPS6KA3 | SIGNOR-248320 |
| PPM1D | dephosphorylation → down-regulates activity | RPS6KA3 | SIGNOR-248321 |
| PPM1D | dephosphorylation → down-regulates activity | RPS6KA3 | SIGNOR-248322 |
| PPM1D | dephosphorylation → down-regulates activity | RPS6KA3 | SIGNOR-248323 |
| PPM1D | dephosphorylation down-regulates | MAPK12 | SIGNOR-135976 |
| PPM1D | dephosphorylation down-regulates quantity by destabilization | MDM2 | SIGNOR-248324 |
| PPM1D | dephosphorylation → up-regulates | MDM2 | SIGNOR-158328 |
| PPM1D | dephosphorylation → down-regulates activity | BAX | SIGNOR-276993 |
| PPM1D | dephosphorylation → down-regulates activity | TP53BP1 | SIGNOR-277046 |
| PPM1D | dephosphorylation down-regulates | ATM | SIGNOR-185135 |
| PPM1D | dephosphorylation → down-regulates activity | ATM | SIGNOR-248325 |
| PPM1D | dephosphorylation → down-regulates activity | ATM | SIGNOR-276954 |
| PPM1D | dephosphorylation → down-regulates activity | ATM | SIGNOR-276955 |
| PPM1D | dephosphorylation → up-regulates activity | RUNX2 | SIGNOR-277110 |
| PPM1D | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-84793 |
| PPM1D | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-187770 |
| PPM1D | dephosphorylation → up-regulates activity | RBM38 | SIGNOR-277020 |