Summary

Name PPM1D
Full Name Protein phosphatase 1D
Synonyms Protein phosphatase 2C isoform delta, PP2C-delta, Protein phosphatase magnesium-dependent 1 delta, p53-induced protein phosphatase 1 | WIP1
Primary ID O15297
Links - -
Type protein
Relations 17
Pathways P38 Signaling
Function Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png dephosphorylation H2AFX 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation TP53
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation ATM
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation RPS6KA3
Publications: 4 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation CHEK1 0.39
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation CHEK1
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation MDM2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation MDM2 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK12 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CHEK2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK14 0.14
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling
+ down-regulates img/direct_inhibition.png dephosphorylation ATM 0.19
Publications: 1 Organism: Homo Sapiens