| Name | PPM1D |
| ID | O15297 |
| Role | substrate |
| Enzymatic Domains |
PPM-type phosphatase 8-375 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HIPK2 | PPM1D | Ser54 | QPLPPRPsPAALPGG | phosphorylation down-regulates quantity by destabilization | 27308327 | SIGNOR-278229 |
| HIPK2 | PPM1D | Ser54 | QPLPPRPsPAALPGG | phosphorylation down-regulates quantity by destabilization | 23871434 | SIGNOR-275480 |
| HIPK2 | PPM1D | Ser85 | PLPDAGAsPAPSRCC | phosphorylation down-regulates quantity by destabilization | 23871434 | SIGNOR-275481 |
| CDK1 | PPM1D | Ser40 | PTAEEKPsPRRSLSQ | phosphorylation down-regulates quantity by destabilization | 33309518 | SIGNOR-275489 |
| CyclinB/CDK1 | PPM1D | Ser40 | PTAEEKPsPRRSLSQ | dephosphorylation down-regulates quantity by destabilization | 33309518 | SIGNOR-275490 |
| HIPK2 | PPM1D | Ser85 | PLPDAGAsPAPSRCC | phosphorylation down-regulates quantity by destabilization | 27308327 | SIGNOR-278230 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HIPK2 | phosphorylation up-regulates → | PPM1D PSer54 | phosphorylation down-regulates ⊣ | PPM1D | 27308327 | SIGNOR-278229 |
| HIPK2 | phosphorylation up-regulates → | PPM1D PSer54 | phosphorylation down-regulates ⊣ | PPM1D | 23871434 | SIGNOR-275480 |
| HIPK2 | phosphorylation up-regulates → | PPM1D PSer85 | phosphorylation down-regulates ⊣ | PPM1D | 23871434 | SIGNOR-275481 |
| CDK1 | phosphorylation up-regulates → | PPM1D PSer40 | phosphorylation down-regulates ⊣ | PPM1D | 33309518 | SIGNOR-275489 |
| CyclinB/CDK1 | dephosphorylation down-regulates ⊣ | PPM1D PSer40 | dephosphorylation up-regulates → | PPM1D | 33309518 | SIGNOR-275490 |
| HIPK2 | phosphorylation up-regulates → | PPM1D PSer85 | phosphorylation down-regulates ⊣ | PPM1D | 27308327 | SIGNOR-278230 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| HIPK2 | phosphorylation down-regulates quantity by destabilization | PPM1D | SIGNOR-278229 |
| HIPK2 | phosphorylation down-regulates quantity by destabilization | PPM1D | SIGNOR-275480 |
| HIPK2 | phosphorylation down-regulates quantity by destabilization | PPM1D | SIGNOR-275481 |
| CDK1 | phosphorylation down-regulates quantity by destabilization | PPM1D | SIGNOR-275489 |
| CyclinB/CDK1 | dephosphorylation down-regulates quantity by destabilization | PPM1D | SIGNOR-275490 |
| HIPK2 | phosphorylation down-regulates quantity by destabilization | PPM1D | SIGNOR-278230 |