| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHUK | TP73 | – | phosphorylation up-regulates activity | 22084676 | SIGNOR-279697 | |
| PRKCD | TP73 | Ser289 | GQVLGRRsFEGRICA | phosphorylation up-regulates | 12097319 | SIGNOR-90279 |
| CDK1 | TP73 | Thr86 | AASASPYtPEHAASV | phosphorylation down-regulates activity | 12676926 | SIGNOR-99742 |
| ABL1 | TP73 | Tyr99 | SVPTHSPyAQPSSTF | phosphorylation up-regulates | 10391251 | SIGNOR-68931 |
| CDK2 | TP73 | Thr86 | AASASPYtPEHAASV | phosphorylation down-regulates activity | 12676926 | SIGNOR-99746 |
| PRKCB | TP73 | Ser388 | VPQPLVDsYRQQQQL | phosphorylation up-regulates activity | 19158275 | SIGNOR-276234 |
| PRKCA | TP73 | Ser388 | VPQPLVDsYRQQQQL | phosphorylation up-regulates activity | 19158275 | SIGNOR-276235 |
| CHEK1 | TP73 | Ser47 | EVVGGTDsSMDVFHL | phosphorylation up-regulates | 14585975 | SIGNOR-118913 |
| AURKA | TP73 | Ser235 | DPVTGRQsVVVPYEP | phosphorylation down-regulates activity | 22340593 | SIGNOR-278263 |
| PLK2 | TP73 | Ser48 | VVGGTDSsMDVFHLE | phosphorylation down-regulates activity | 26625870 | SIGNOR-278218 |
| PLK3 | TP73 | – | phosphorylation down-regulates activity | 19490146 | SIGNOR-279647 | |
| MAPK8 | TP73 | – | phosphorylation up-regulates activity | 23516355 | SIGNOR-279219 | |
| CyclinE/CDK2 | TP73 | Thr86 | AASASPYtPEHAASV | phosphorylation down-regulates | 12676926 | SIGNOR-216702 |
| PLK1 | TP73 | Thr27 | SSLEPDStYFDLPQS | phosphorylation down-regulates | 18418051 | SIGNOR-178253 |
| CyclinB/CDK1 | TP73 | Thr86 | AASASPYtPEHAASV | phosphorylation down-regulates | 12676926 | SIGNOR-216849 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCD | phosphorylation up-regulates → | TP73 PSer289 | phosphorylation up-regulates → | TP73 | 12097319 | SIGNOR-90279 |
| CDK1 | phosphorylation up-regulates → | TP73 PThr86 | phosphorylation down-regulates ⊣ | TP73 | 12676926 | SIGNOR-99742 |
| ABL1 | phosphorylation up-regulates → | TP73 PTyr99 | phosphorylation up-regulates → | TP73 | 10391251 | SIGNOR-68931 |
| CDK2 | phosphorylation up-regulates → | TP73 PThr86 | phosphorylation down-regulates ⊣ | TP73 | 12676926 | SIGNOR-99746 |
| PRKCB | phosphorylation up-regulates → | TP73 PSer388 | phosphorylation up-regulates → | TP73 | 19158275 | SIGNOR-276234 |
| PRKCA | phosphorylation up-regulates → | TP73 PSer388 | phosphorylation up-regulates → | TP73 | 19158275 | SIGNOR-276235 |
| CHEK1 | phosphorylation up-regulates → | TP73 PSer47 | phosphorylation up-regulates → | TP73 | 14585975 | SIGNOR-118913 |
| AURKA | phosphorylation up-regulates → | TP73 PSer235 | phosphorylation down-regulates ⊣ | TP73 | 22340593 | SIGNOR-278263 |
| PLK2 | phosphorylation up-regulates → | TP73 PSer48 | phosphorylation down-regulates ⊣ | TP73 | 26625870 | SIGNOR-278218 |
| CyclinE/CDK2 | phosphorylation up-regulates → | TP73 PThr86 | phosphorylation down-regulates ⊣ | TP73 | 12676926 | SIGNOR-216702 |
| PLK1 | phosphorylation up-regulates → | TP73 PThr27 | phosphorylation down-regulates ⊣ | TP73 | 18418051 | SIGNOR-178253 |
| CyclinB/CDK1 | phosphorylation up-regulates → | TP73 PThr86 | phosphorylation down-regulates ⊣ | TP73 | 12676926 | SIGNOR-216849 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHUK | phosphorylation → up-regulates activity | TP73 | SIGNOR-279697 |
| PRKCD | phosphorylation → up-regulates | TP73 | SIGNOR-90279 |
| CDK1 | phosphorylation → down-regulates activity | TP73 | SIGNOR-99742 |
| ABL1 | phosphorylation → up-regulates | TP73 | SIGNOR-68931 |
| CDK2 | phosphorylation → down-regulates activity | TP73 | SIGNOR-99746 |
| PRKCB | phosphorylation → up-regulates activity | TP73 | SIGNOR-276234 |
| PRKCA | phosphorylation → up-regulates activity | TP73 | SIGNOR-276235 |
| CHEK1 | phosphorylation → up-regulates | TP73 | SIGNOR-118913 |
| AURKA | phosphorylation → down-regulates activity | TP73 | SIGNOR-278263 |
| PLK2 | phosphorylation → down-regulates activity | TP73 | SIGNOR-278218 |
| PLK3 | phosphorylation → down-regulates activity | TP73 | SIGNOR-279647 |
| MAPK8 | phosphorylation → up-regulates activity | TP73 | SIGNOR-279219 |
| CyclinE/CDK2 | phosphorylation down-regulates | TP73 | SIGNOR-216702 |
| PLK1 | phosphorylation down-regulates | TP73 | SIGNOR-178253 |
| CyclinB/CDK1 | phosphorylation down-regulates | TP73 | SIGNOR-216849 |
