Summary

Name TP73
Full Name Tumor protein p73
Synonyms p53-like transcription factor, p53-related protein | P73
Primary ID O15350
Links - -
Type protein
Relations 18
Function Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation TP73 0.15
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP73 0.23
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP73 0.17
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP73
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP73 0.17
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP73 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP73 0.17
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP73
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP73 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP73 0.20
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP73
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BBC3 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PMAIP1 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TP73 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png unknown TP73
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown Apoptosis
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP73 0.18
Publications: 1 Organism: Homo Sapiens