Entity Details

Name TP73_Thr86
ID O15350
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK1TP73Thr86AASASPYtPEHAASVphosphorylation
down-regulates activity		12676926SIGNOR-99742
CDK2TP73Thr86AASASPYtPEHAASVphosphorylation
down-regulates activity		12676926SIGNOR-99746
CyclinE/CDK2TP73Thr86AASASPYtPEHAASVphosphorylation
down-regulates		12676926SIGNOR-216702
CyclinB/CDK1TP73Thr86AASASPYtPEHAASVphosphorylation
down-regulates		12676926SIGNOR-216849
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK1phosphorylation
up-regulates
→
TP73
PThr86		phosphorylation
down-regulates
⊣		TP7312676926SIGNOR-99742
CDK2phosphorylation
up-regulates
→
TP73
PThr86		phosphorylation
down-regulates
⊣		TP7312676926SIGNOR-99746
CyclinE/CDK2phosphorylation
up-regulates
→
TP73
PThr86		phosphorylation
down-regulates
⊣		TP7312676926SIGNOR-216702
CyclinB/CDK1phosphorylation
up-regulates
→
TP73
PThr86		phosphorylation
down-regulates
⊣		TP7312676926SIGNOR-216849
Regulator Mechanism/Effect Target SIGNOR-ID
CDK1phosphorylation
→
down-regulates activity 		TP73SIGNOR-99742
CDK2phosphorylation
→
down-regulates activity 		TP73SIGNOR-99746
CyclinE/CDK2phosphorylation
img/direct_inhibition.png
down-regulates 		TP73SIGNOR-216702
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates 		TP73SIGNOR-216849