| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKB | BIRC5 | Thr117 | KNKIAKEtNNKKKEF | phosphorylation down-regulates | 17457057 | SIGNOR-154569 |
| CDK1 | BIRC5 | Thr34 | FLEGCACtPERMAEA | phosphorylation up-regulates | 11861764 | SIGNOR-115129 |
| PLK1 | BIRC5 | Ser20 | FLKDHRIsTFKNWPF | phosphorylation up-regulates | 21148584 | SIGNOR-170460 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKB | phosphorylation up-regulates → | BIRC5 PThr117 | phosphorylation down-regulates ⊣ | BIRC5 | 17457057 | SIGNOR-154569 |
| CDK1 | phosphorylation up-regulates → | BIRC5 PThr34 | phosphorylation up-regulates → | BIRC5 | 11861764 | SIGNOR-115129 |
| PLK1 | phosphorylation up-regulates → | BIRC5 PSer20 | phosphorylation up-regulates → | BIRC5 | 21148584 | SIGNOR-170460 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKB | phosphorylation down-regulates | BIRC5 | SIGNOR-154569 |
| CDK1 | phosphorylation → up-regulates | BIRC5 | SIGNOR-115129 |
| PLK1 | phosphorylation → up-regulates | BIRC5 | SIGNOR-170460 |
