Summary

Name BIRC5
Full Name Baculoviral IAP repeat-containing protein 5
Synonyms Apoptosis inhibitor 4, Apoptosis inhibitor survivin | API4, IAP4
Primary ID O15392
Links - -
Type protein
Relations 14
Function Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation BIRC5 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BIRC5 0.56
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BIRC5 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BIRC5 0.09
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding DIABLO 0.43
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CASP9 0.32
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CASP3 0.42
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BIRC5 0.43
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation BIRC5 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding XIAP 0.77
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BIRC5 0.16
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BIRC5 0.16
Publications: 1 Organism: Homo Sapiens