Entity Details

Name TLR3
ID O15455
Role substrate
Enzymatic Domains
LRRNT 24-51
LRRCT 645-698
TIR 754-897
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
EGFRTLR3Tyr858FLEEIPDyKLNHALCphosphorylation
up-regulates activity		25022196SIGNOR-278932
SRCTLR3Tyr759EQFEYAAyIIHAYKDphosphorylation
up-regulates activity		27514533SIGNOR-279657
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
EGFRphosphorylation
up-regulates
→
TLR3
PTyr858		phosphorylation
up-regulates
→		TLR325022196SIGNOR-278932
SRCphosphorylation
up-regulates
→
TLR3
PTyr759		phosphorylation
up-regulates
→		TLR327514533SIGNOR-279657
Regulator Mechanism/Effect Target SIGNOR-ID
EGFRphosphorylation
→
up-regulates activity 		TLR3SIGNOR-278932
SRCphosphorylation
→
up-regulates activity 		TLR3SIGNOR-279657