| Name | CLOCK |
| ID | O15516 |
| Role | substrate |
| Enzymatic Domains |
bHLH 34-84 PROSITE-ProRule
PAS 1 107-177 PROSITE-ProRule
PAS 2 262-332 PROSITE-ProRule
PAC 336-379 |
View in  |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | CLOCK | Ser427 | ALERFDHsPTPSASS | phosphorylation down-regulates quantity by destabilization | 19946213 | SIGNOR-276270 |
| CDK5 | CLOCK | Thr451 | AVSDPSStPTKIPTD | phosphorylation up-regulates | 24235147 | SIGNOR-203227 |
| CDK5 | CLOCK | Thr461 | KIPTDTStPPRQHLP | phosphorylation up-regulates | 24235147 | SIGNOR-203231 |
| GSK3B | CLOCK | – | phosphorylation down-regulates quantity by destabilization | 19946213 | SIGNOR-279741 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | CLOCK PSer427 | phosphorylation down-regulates ⊣ | CLOCK | 19946213 | SIGNOR-276270 |
| CDK5 | phosphorylation up-regulates → | CLOCK PThr451 | phosphorylation up-regulates → | CLOCK | 24235147 | SIGNOR-203227 |
| CDK5 | phosphorylation up-regulates → | CLOCK PThr461 | phosphorylation up-regulates → | CLOCK | 24235147 | SIGNOR-203231 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation down-regulates quantity by destabilization | CLOCK | SIGNOR-276270 |
| CDK5 | phosphorylation → up-regulates | CLOCK | SIGNOR-203227 |
| CDK5 | phosphorylation → up-regulates | CLOCK | SIGNOR-203231 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | CLOCK | SIGNOR-279741 |