| + |
GSK3B | down-regulates quantity by destabilization 
phosphorylation
|
CLOCK |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276270 |
Ser427 |
ALERFDHsPTPSASS |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 19946213 |
We have identified a conserved cluster of serines that include, Ser431, which is a prerequisite phosphorylation site for the generation of BMAL dependent phospho-primed CLOCK and for the potential GSK-3 phosphorylation at Ser427. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279741 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19946213 |
The results showed that recombinant GSK-3\u03b2 can specifically phosphorylate CLOCK and that this phosphorylation is abrogated in the presence of GSK-3 inhibitor BIO ( xref ).|the over-expression of constitutive active GSK-3β increases an unstable phospho-CLOCK while an inactive GSK-3β inhibits phosphorylation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDK5 | up-regulates 
phosphorylation
|
CLOCK |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203227 |
Thr451 |
AVSDPSStPTKIPTD |
Homo sapiens |
|
| pmid |
sentence |
| 24235147 |
Cdk5 phosphorylates clock at the thr-451 and thr-461 residues in association with transcriptional activation of clock. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203231 |
Thr461 |
KIPTDTStPPRQHLP |
Homo sapiens |
|
| pmid |
sentence |
| 24235147 |
Cdk5 phosphorylates clock at the thr-451 and thr-461 residues in association with transcriptional activation of clock. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RAI1 | up-regulates quantity by expression
transcriptional regulation
|
CLOCK |
0.478 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266839 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22578325 |
RAI1 Transcriptionally Activates CLOCK via an Intron 1 Enhancer Element. data suggest that RAI1 binds, directly or in a complex, to the first intron of CLOCK and enhances its transcriptional activity in vitro, supporting RAI1 as a positive regulator of CLOCK and an important part of the circadian loop of transcription. Data further show that haploinsufficiency of RAI1 and Rai1 in SMS fibroblasts and the mouse hypothalamus, respectively, results in the transcriptional dysregulation of the circadian clock and causes altered expression and regulation of multiple circadian genes, including PER2, PER3, CRY1, BMAL1, and others. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Circadian clock |
| + |
CLOCK | up-regulates quantity by expression
transcriptional regulation
|
NR0B2 |
0.388 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253698 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20674862 |
CLOCK knockdown activated MTP promoter and reduced small heterodimer partner (SHP, NROB2). CLOCK upregulated SHP by binding to its E box. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CLOCK | down-regulates quantity by repression
transcriptional regulation
|
NR3C1 |
0.41 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253699 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21164265 |
We recently reported that the basic helix-loop- helix transcription factor Clock, which is a histone acetyltransferase and a central component of the self-oscillating transcription factor loop that generates circadian rhythms, represses GR transcriptional activity by acetylating lysine residues within the 'lysine cluster' located in the hinge region of the receptor. This Clock-mediated repression of GR transcriptional activity oscillates in inverse phase to the HPA axis, acting as a target tissue counter-regulatory mechanism to the diurnally fluctuating circulating glucocorticoids. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
CLOCK | up-regulates quantity by expression 
transcriptional regulation
|
PER3 |
0.572 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253635 |
|
|
|
|
| pmid |
sentence |
| 22750052 |
Mammalian clocks are primarily based on a transcription and translation feedback loop in which a heterodimeric complex of the transcription factors CLOCK (circadian locomotor output cycles kaput) and BMAL1 (brain and muscle Arnt-like protein 1) activates the expression of its own repressors, the period (PER1-3) and cryptochrome (CRY1,2) proteins. |
|
| Publications: |
1 |
| Pathways: | Circadian clock |
| + |
CLOCK | up-regulates quantity by expression
transcriptional regulation
|
PER2 |
0.778 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253634 |
|
|
|
|
| pmid |
sentence |
| 22750052 |
Mammalian clocks are primarily based on a transcription and translation feedback loop in which a heterodimeric complex of the transcription factors CLOCK (circadian locomotor output cycles kaput) and BMAL1 (brain and muscle Arnt-like protein 1) activates the expression of its own repressors, the period (PER1-3) and cryptochrome (CRY1,2) proteins. |
|
| Publications: |
1 |
| Pathways: | Circadian clock |
| + |
CLOCK | up-regulates quantity by expression
transcriptional regulation
|
DPYD |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253986 |
|
|
|
|
| pmid |
sentence |
| 17699798 |
Regulation of Genes of the Circadian Clock in Human Colon Cancer: Reduced Period-1 and Dihydropyrimidine Dehydrogenase Transcription Correlates in High-Grade Tumors| The highly significant correlation of DPD mRNA with Per1 mRNA expression suggests control of DPD transcription by the endogenous cellular clock, which is more pronounced in women. |
|
| Publications: |
1 |
| + |
CLOCK | form complex 
binding
|
CLOCK/BMAL2 |
0.683 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253711 |
|
|
|
|
| pmid |
sentence |
| 19605937 |
Like BMAL1, its paralog BMAL2 dimerizes with CLOCK to activate the E-box-dependent transcription |
|
| Publications: |
1 |
| Pathways: | Circadian clock |
| + |
CLOCK | up-regulates quantity by expression
transcriptional regulation
|
CRY2 |
0.925 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253632 |
|
|
|
|
| pmid |
sentence |
| 22750052 |
Mammalian clocks are primarily based on a transcription and translation feedback loop in which a heterodimeric complex of the transcription factors CLOCK (circadian locomotor output cycles kaput) and BMAL1 (brain and muscle Arnt-like protein 1) activates the expression of its own repressors, the period (PER1-3) and cryptochrome (CRY1,2) proteins. |
|
| Publications: |
1 |
| Pathways: | Circadian clock |
| + |
CLOCK | form complex
binding
|
CLOCK/BMAL1 |
0.781 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253709 |
|
|
in vitro |
|
| pmid |
sentence |
| 22653727 |
Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex|The structure of the CLOCK:BMAL1 complex is a starting point for understanding at an atomic level the mechanism driving the mammalian circadian clock. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Circadian clock |
| + |
CLOCK | up-regulates quantity by expression
transcriptional regulation
|
PER1 |
0.732 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253633 |
|
|
|
|
| pmid |
sentence |
| 22750052 |
Mammalian clocks are primarily based on a transcription and translation feedback loop in which a heterodimeric complex of the transcription factors CLOCK (circadian locomotor output cycles kaput) and BMAL1 (brain and muscle Arnt-like protein 1) activates the expression of its own repressors, the period (PER1-3) and cryptochrome (CRY1,2) proteins. |
|
| Publications: |
1 |
| Pathways: | Circadian clock |
| + |
CLOCK | down-regulates activity
binding
|
MAGEL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253516 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22208286 |
Magel2 represses the activity of the Clock:Bmal1 heterodimer in a Per2-luciferase assay. Magel2 interacts with Bmal1 and with Per2 as measured by co-immunoprecipitation in co-transfected cells, and exhibits a subcellular distribution consistent with these interactions when visualized by immunofluorescence. As well, Magel2 induces the redistribution of the subcellular localization of Clock towards the cytoplasm, in contrast to the nucleus-directed effect of Bmal1 on Clock subcellular localization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CLOCK | form complex
binding
|
BMAL1/NPAS2 |
0.539 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267965 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20817722 |
The mammalian clock is regulated at the cellular level by a transcriptional/translational feedback loop. BMAL1/clock (or NPAS2) heterodimers activate the expression of the period (PER) and cryptochrome (CRY) genes acting as transcription factors directed to the PER and CRY promoters via E-box elements. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
CLOCK | up-regulates quantity by expression
transcriptional regulation
|
CRY1 |
0.945 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253631 |
|
|
|
|
| pmid |
sentence |
| 22750052 |
Mammalian clocks are primarily based on a transcription and translation feedback loop in which a heterodimeric complex of the transcription factors CLOCK (circadian locomotor output cycles kaput) and BMAL1 (brain and muscle Arnt-like protein 1) activates the expression of its own repressors, the period (PER1-3) and cryptochrome (CRY1,2) proteins. |
|
| Publications: |
1 |
| Pathways: | Circadian clock |
3.0
CLOCK
- 
- 