Entity Details

Name CFLAR
ID O15519
Role substrate
Enzymatic Domains
DED 1 1-73
PROSITE-ProRule
DED 2 92-170
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
AKT1CFLARSer273LLRDTFTsLGYEVQKphosphorylation
down-regulates quantity		19339247SIGNOR-252548
MAPK14CFLAR–phosphorylation
up-regulates		19597496SIGNOR-187001
PRKCACFLARSer193LQAAIQKsLKDPSNNphosphorylation
up-regulates quantity by stabilization		19343040SIGNOR-276147
PRKCBCFLARSer193LQAAIQKsLKDPSNNphosphorylation
up-regulates quantity by stabilization		19343040SIGNOR-276146
AKTCFLARSer273LLRDTFTsLGYEVQKphosphorylation
down-regulates quantity		19339247SIGNOR-245304
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
AKT1phosphorylation
up-regulates
→
CFLAR
PSer273		phosphorylation
down-regulates
⊣		CFLAR19339247SIGNOR-252548
PRKCAphosphorylation
up-regulates
→
CFLAR
PSer193		phosphorylation
up-regulates
→		CFLAR19343040SIGNOR-276147
PRKCBphosphorylation
up-regulates
→
CFLAR
PSer193		phosphorylation
up-regulates
→		CFLAR19343040SIGNOR-276146
AKTphosphorylation
up-regulates
→
CFLAR
PSer273		phosphorylation
down-regulates
⊣		CFLAR19339247SIGNOR-245304
Regulator Mechanism/Effect Target SIGNOR-ID
AKT1phosphorylation
→
down-regulates quantity 		CFLARSIGNOR-252548
MAPK14phosphorylation
→
up-regulates 		CFLARSIGNOR-187001
PRKCAphosphorylation
→
up-regulates quantity by stabilization 		CFLARSIGNOR-276147
PRKCBphosphorylation
→
up-regulates quantity by stabilization 		CFLARSIGNOR-276146
AKTphosphorylation
→
down-regulates quantity 		CFLARSIGNOR-245304