Summary

Name CFLAR
Full Name CASP8 and FADD-like apoptosis regulator
Synonyms Caspase homolog, CASH, Caspase-eight-related protein, Casper, Caspase-like apoptosis regulatory protein, CLARP, Cellular FLICE-like inhibitory protein, c-FLIP, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, I-FLICE, MACH-related inducer of toxicity, MRIT, Usurpin | CASH, CASP8AP1, CLARP, MRIT
Primary ID O15519
Links - -
Type protein
Relations 8
Pathways Death Receptor Signaling
Function Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png phosphorylation CFLAR 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation CFLAR 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CFLAR 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CASP8 0.61
Publications: 2 Organism: Homo Sapiens
Tissue: Skeletal Muscle, Heart, Lymphoid Tissue
Pathways:Death Receptor Signaling
+ down-regulates quantity img/direct_inhibition.png ubiquitination CFLAR 0.08
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation CFLAR 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CFLAR 0.08
Publications: 1 Organism: Homo Sapiens