Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
LYN	SOCS1	Tyr80	LLDACGFyWGPLSVH	phosphorylation down-regulates activity	31101761	SIGNOR-277888
BLK	SOCS1	Tyr80	LLDACGFyWGPLSVH	phosphorylation down-regulates activity	31101761	SIGNOR-277889
YES1	SOCS1	Tyr80	LLDACGFyWGPLSVH	phosphorylation up-regulates quantity by stabilization	31101761	SIGNOR-277453
YES1	SOCS1	Tyr80	LLDACGFyWGPLSVH	phosphorylation down-regulates activity	31101761	SIGNOR-276858
SRC	SOCS1	Tyr80	LLDACGFyWGPLSVH	phosphorylation down-regulates activity	31101761	SIGNOR-276857

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
LYN	phosphorylation up-regulates →	SOCS1 PTyr80	phosphorylation down-regulates ⊣	SOCS1	31101761	SIGNOR-277888
BLK	phosphorylation up-regulates →	SOCS1 PTyr80	phosphorylation down-regulates ⊣	SOCS1	31101761	SIGNOR-277889
YES1	phosphorylation up-regulates →	SOCS1 PTyr80	phosphorylation up-regulates →	SOCS1	31101761	SIGNOR-277453
YES1	phosphorylation up-regulates →	SOCS1 PTyr80	phosphorylation down-regulates ⊣	SOCS1	31101761	SIGNOR-276858
SRC	phosphorylation up-regulates →	SOCS1 PTyr80	phosphorylation down-regulates ⊣	SOCS1	31101761	SIGNOR-276857

Regulator	Mechanism/Effect	Target	SIGNOR-ID
LYN	phosphorylation → down-regulates activity	SOCS1	SIGNOR-277888
BLK	phosphorylation → down-regulates activity	SOCS1	SIGNOR-277889
YES1	phosphorylation → up-regulates quantity by stabilization	SOCS1	SIGNOR-277453
YES1	phosphorylation → down-regulates activity	SOCS1	SIGNOR-276858
SRC	phosphorylation → down-regulates activity	SOCS1	SIGNOR-276857