4.0
Summary
| Name |  SOCS1View Modifications |
| Full Name | Suppressor of cytokine signaling 1 |
| Synonyms | SOCS-1, JAK-binding protein, JAB, STAT-induced STAT inhibitor 1, SSI-1, Tec-interacting protein 3, TIP-3 | SSI1, TIP3 |
| Primary ID | O15524 |
| Links |  -  -  |
| Type | protein |
| Relations | 22 |
| Pathways | IL6 Signaling, LIF in PDAC, Macrophage polarization, Macrophage: IFN gamma, Macrophage: IL4, Macrophage: IL6, Macrophage: Polarization and myogenesis, Monocyte: Macrophage differentiation, Satellite: IL6 |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | YES1 | down-regulates activity 
phosphorylation
|
SOCS1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | BLK | down-regulates activity
phosphorylation
|
SOCS1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | LYN | down-regulates activity
phosphorylation
|
SOCS1 | 0.302 |
| Publications: | 1 | Organism: | In Vitro | |
| + | YES1 | up-regulates quantity by stabilization 
phosphorylation
|
SOCS1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SRC | down-regulates activity
phosphorylation
|
SOCS1 | 0.452 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | IL6 Signaling | |||
| + | SOCS1 | down-regulates 
|
IFNG | 0.556 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization | |||
| + | SOCS1 | up-regulates activity
binding
|
VCB-Cul2 | 0.548 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | IFNG | up-regulates quantity by expression 
transcriptional regulation
|
SOCS1 | 0.556 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization | |||
| + | SOCS1 | down-regulates
binding
|
JAK1 | 0.732 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | IL6 Signaling | |||
| + | SOCS1 | down-regulates quantity by destabilization
binding
|
VAV1 | 0.596 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | SOCS1 | down-regulates quantity by repression
transcriptional regulation
|
STAT1 | 0.628 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | STAT6 | up-regulates quantity by expression
transcriptional regulation
|
SOCS1 | 0.639 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization | |||
| + | SOCS1 | down-regulates
binding
|
IRAK1 | 0.403 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPN6 | up-regulates
binding
|
SOCS1 | 0.326 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | STAT1 | up-regulates quantity by expression
transcriptional regulation
|
SOCS1 | 0.628 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSF1R | up-regulates quantity by expression
transcriptional regulation
|
SOCS1 | 0.49 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SOCS1 | down-regulates activity
binding
|
JAK3 | 0.708 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SOCS1 | down-regulates
binding
|
IFNGR1 | 0.674 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SOCS1 | down-regulates quantity by destabilization
ubiquitination
|
JAK2 | 0.795 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization | |||
| + | IRF1 | up-regulates quantity by expression
transcriptional regulation
|
SOCS1 | 0.383 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SOCS1 | down-regulates
|
Proliferation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | IL6 Signaling | |||