Summary

Name SOCS1
Full Name Suppressor of cytokine signaling 1
Synonyms SOCS-1, JAK-binding protein, JAB, STAT-induced STAT inhibitor 1, SSI-1, Tec-interacting protein 3, TIP-3 | SSI1, TIP3
Primary ID O15524
Links - -
Type protein
Relations 17
Pathways IL6 Signaling, Macrophage polarization, Macrophage: IFN gamma, Macrophage: IL4, Macrophage: IL6, Macrophage: Polarization and myogenesis, Monocyte: Macrophage differentiation, Satellite: IL6
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

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Relations

Regulator Mechanism target score
+ down-regulates img/indirect_inhibition.png IFNG 0.536
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination JAK2 0.787
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization
+ down-regulates img/direct_inhibition.png binding IFNGR1 0.658
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOCS1 0.536
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation STAT1 0.626
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding VCB-Cul2 0.526
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOCS1 0.506
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding JAK1 0.72
Publications: 2 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOCS1 0.626
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding VAV1 0.576
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding SOCS1 0.334
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding IRAK1 0.416
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOCS1 0.624
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOCS1 0.394
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding JAK3 0.695
Publications: 1 Organism: Homo Sapiens