| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| YES1 | SOCS1 | Tyr80 | LLDACGFyWGPLSVH | phosphorylation down-regulates activity | 31101761 | SIGNOR-276858 |
| SRC | SOCS1 | Tyr80 | LLDACGFyWGPLSVH | phosphorylation down-regulates activity | 31101761 | SIGNOR-276857 |
| LYN | SOCS1 | Tyr80 | LLDACGFyWGPLSVH | phosphorylation down-regulates activity | 31101761 | SIGNOR-277888 |
| BLK | SOCS1 | Tyr80 | LLDACGFyWGPLSVH | phosphorylation down-regulates activity | 31101761 | SIGNOR-277889 |
| YES1 | SOCS1 | Tyr80 | LLDACGFyWGPLSVH | phosphorylation up-regulates quantity by stabilization | 31101761 | SIGNOR-277453 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| YES1 | phosphorylation up-regulates → | SOCS1 PTyr80 | phosphorylation down-regulates ⊣ | SOCS1 | 31101761 | SIGNOR-276858 |
| SRC | phosphorylation up-regulates → | SOCS1 PTyr80 | phosphorylation down-regulates ⊣ | SOCS1 | 31101761 | SIGNOR-276857 |
| LYN | phosphorylation up-regulates → | SOCS1 PTyr80 | phosphorylation down-regulates ⊣ | SOCS1 | 31101761 | SIGNOR-277888 |
| BLK | phosphorylation up-regulates → | SOCS1 PTyr80 | phosphorylation down-regulates ⊣ | SOCS1 | 31101761 | SIGNOR-277889 |
| YES1 | phosphorylation up-regulates → | SOCS1 PTyr80 | phosphorylation up-regulates → | SOCS1 | 31101761 | SIGNOR-277453 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| YES1 | phosphorylation → down-regulates activity | SOCS1 | SIGNOR-276858 |
| SRC | phosphorylation → down-regulates activity | SOCS1 | SIGNOR-276857 |
| LYN | phosphorylation → down-regulates activity | SOCS1 | SIGNOR-277888 |
| BLK | phosphorylation → down-regulates activity | SOCS1 | SIGNOR-277889 |
| YES1 | phosphorylation → up-regulates quantity by stabilization | SOCS1 | SIGNOR-277453 |