| Name | PDPK1 |
| ID | O15530 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 82-342 PROSITE-ProRule
PH 459-550 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PGK1 | PDPK1 | – | phosphorylation up-regulates activity | 32646968 | SIGNOR-280064 | |
| RPS6KB1 | PDPK1 | Ser549 | VWRQRYQsHPDAAVQ | phosphorylation down-regulates activity | 35318320 | SIGNOR-273844 |
| IGF1R | PDPK1 | Tyr376 | DEDCYGNyDNLLSQF | phosphorylation up-regulates | 20643654 | SIGNOR-166714 |
| PDPK1 | PDPK1 | Ser410 | GLPQRSGsNIEQYIH | phosphorylation unknown | 10455013 | SIGNOR-236772 |
| SRC | PDPK1 | Tyr9 | ARTTSQLyDAVPIQS | phosphorylation up-regulates activity | 11481331 | SIGNOR-109533 |
| RET | PDPK1 | Tyr9 | ARTTSQLyDAVPIQS | phosphorylation up-regulates activity | 12738763 | SIGNOR-235863 |
| PDPK1 | PDPK1 | Ser241 | SKQARANsFVGTAQY | phosphorylation up-regulates activity | 11481331 | SIGNOR-250268 |
| IGF1R | PDPK1 | Tyr373 | SEDDEDCyGNYDNLL | phosphorylation up-regulates | 20044479 | SIGNOR-236548 |
| SRC | PDPK1 | Tyr376 | DEDCYGNyDNLLSQF | phosphorylation up-regulates | 20643654 | SIGNOR-166722 |
| MELK | PDPK1 | Thr354 | WENLHQQtPPKLTAY | phosphorylation down-regulates activity | 22544756 | SIGNOR-276414 |
| PP2Ca_R1A_Bd | PDPK1 | – | dephosphorylation down-regulates activity | 21075311 | SIGNOR-243515 | |
| IGF1R | PDPK1 | Tyr376 | DEDCYGNyDNLLSQF | phosphorylation up-regulates | 20044479 | SIGNOR-236544 |
| FGFR1 | PDPK1 | – | phosphorylation up-regulates activity | 22195962 | SIGNOR-279174 | |
| IGF1R | PDPK1 | Tyr373 | SEDDEDCyGNYDNLL | phosphorylation up-regulates | 20643654 | SIGNOR-166710 |
| PDPK1 | PDPK1 | Ser396 | SSSSSSHsLSASDTG | phosphorylation unknown | 10455013 | SIGNOR-236764 |
| PDPK1 | PDPK1 | Ser25 | VVLCSCPsPSMVRTQ | phosphorylation unknown | 10455013 | SIGNOR-236777 |
| SRC | PDPK1 | Tyr373 | SEDDEDCyGNYDNLL | phosphorylation up-regulates | 20643654 | SIGNOR-166718 |
| PDPK1 | PDPK1 | Ser393 | MQVSSSSsSHSLSAS | phosphorylation unknown | 10455013 | SIGNOR-235782 |
| PDPK1 | PDPK1 | Ser241 | SKQARANsFVGTAQY | phosphorylation down-regulates quantity by destabilization | 12177059 | SIGNOR-250077 |
| ROCK1 | PDPK1 | – | phosphorylation up-regulates activity | 26241960 | SIGNOR-279758 | |
| PDPK1 | PDPK1 | Ser241 | SKQARANsFVGTAQY | phosphorylation up-regulates activity | 10455013 | SIGNOR-236789 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KB1 | phosphorylation up-regulates → | PDPK1 PSer549 | phosphorylation down-regulates ⊣ | PDPK1 | 35318320 | SIGNOR-273844 |
| IGF1R | phosphorylation up-regulates → | PDPK1 PTyr376 | phosphorylation up-regulates → | PDPK1 | 20643654 | SIGNOR-166714 |
| PDPK1 | phosphorylation up-regulates → | PDPK1 PSer410 | phosphorylation down-regulates ⊣ | PDPK1 | 10455013 | SIGNOR-236772 |
| SRC | phosphorylation up-regulates → | PDPK1 PTyr9 | phosphorylation up-regulates → | PDPK1 | 11481331 | SIGNOR-109533 |
| RET | phosphorylation up-regulates → | PDPK1 PTyr9 | phosphorylation up-regulates → | PDPK1 | 12738763 | SIGNOR-235863 |
| PDPK1 | phosphorylation up-regulates → | PDPK1 PSer241 | phosphorylation up-regulates → | PDPK1 | 11481331 | SIGNOR-250268 |
| IGF1R | phosphorylation up-regulates → | PDPK1 PTyr373 | phosphorylation up-regulates → | PDPK1 | 20044479 | SIGNOR-236548 |
| SRC | phosphorylation up-regulates → | PDPK1 PTyr376 | phosphorylation up-regulates → | PDPK1 | 20643654 | SIGNOR-166722 |
| MELK | phosphorylation up-regulates → | PDPK1 PThr354 | phosphorylation down-regulates ⊣ | PDPK1 | 22544756 | SIGNOR-276414 |
| IGF1R | phosphorylation up-regulates → | PDPK1 PTyr376 | phosphorylation up-regulates → | PDPK1 | 20044479 | SIGNOR-236544 |
| IGF1R | phosphorylation up-regulates → | PDPK1 PTyr373 | phosphorylation up-regulates → | PDPK1 | 20643654 | SIGNOR-166710 |
| PDPK1 | phosphorylation up-regulates → | PDPK1 PSer396 | phosphorylation down-regulates ⊣ | PDPK1 | 10455013 | SIGNOR-236764 |
| PDPK1 | phosphorylation up-regulates → | PDPK1 PSer25 | phosphorylation down-regulates ⊣ | PDPK1 | 10455013 | SIGNOR-236777 |
| SRC | phosphorylation up-regulates → | PDPK1 PTyr373 | phosphorylation up-regulates → | PDPK1 | 20643654 | SIGNOR-166718 |
| PDPK1 | phosphorylation up-regulates → | PDPK1 PSer393 | phosphorylation down-regulates ⊣ | PDPK1 | 10455013 | SIGNOR-235782 |
| PDPK1 | phosphorylation up-regulates → | PDPK1 PSer241 | phosphorylation down-regulates ⊣ | PDPK1 | 12177059 | SIGNOR-250077 |
| PDPK1 | phosphorylation up-regulates → | PDPK1 PSer241 | phosphorylation up-regulates → | PDPK1 | 10455013 | SIGNOR-236789 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PGK1 | phosphorylation → up-regulates activity | PDPK1 | SIGNOR-280064 |
| RPS6KB1 | phosphorylation → down-regulates activity | PDPK1 | SIGNOR-273844 |
| IGF1R | phosphorylation → up-regulates | PDPK1 | SIGNOR-166714 |
| PDPK1 | phosphorylation → unknown | PDPK1 | SIGNOR-236772 |
| SRC | phosphorylation → up-regulates activity | PDPK1 | SIGNOR-109533 |
| RET | phosphorylation → up-regulates activity | PDPK1 | SIGNOR-235863 |
| PDPK1 | phosphorylation → up-regulates activity | PDPK1 | SIGNOR-250268 |
| IGF1R | phosphorylation → up-regulates | PDPK1 | SIGNOR-236548 |
| SRC | phosphorylation → up-regulates | PDPK1 | SIGNOR-166722 |
| MELK | phosphorylation → down-regulates activity | PDPK1 | SIGNOR-276414 |
| PP2Ca_R1A_Bd | dephosphorylation → down-regulates activity | PDPK1 | SIGNOR-243515 |
| IGF1R | phosphorylation → up-regulates | PDPK1 | SIGNOR-236544 |
| FGFR1 | phosphorylation → up-regulates activity | PDPK1 | SIGNOR-279174 |
| IGF1R | phosphorylation → up-regulates | PDPK1 | SIGNOR-166710 |
| PDPK1 | phosphorylation → unknown | PDPK1 | SIGNOR-236764 |
| PDPK1 | phosphorylation → unknown | PDPK1 | SIGNOR-236777 |
| SRC | phosphorylation → up-regulates | PDPK1 | SIGNOR-166718 |
| PDPK1 | phosphorylation → unknown | PDPK1 | SIGNOR-235782 |
| PDPK1 | phosphorylation down-regulates quantity by destabilization | PDPK1 | SIGNOR-250077 |
| ROCK1 | phosphorylation → up-regulates activity | PDPK1 | SIGNOR-279758 |
| PDPK1 | phosphorylation → up-regulates activity | PDPK1 | SIGNOR-236789 |