Summary

Name PDPK1
Full Name 3-phosphoinositide-dependent protein kinase 1
Synonyms hPDK1 | PDK1, PDK1
Primary ID O15530
Links - -
Type protein
Relations 87
Pathways Insulin Receptor, IGF and Myogenesis, Non-small-cell lung cancer (NSCLC), Glioblastoma Multiforme, Malignant Melanoma, EGFR, Acute Myeloid Leukemia, AMPK Signaling, Adipogenesis, Luminal Breast Cancer, Prostate Cancer, T cell activation, Rhabdomyosarcoma, MTOR Signaling, Thyroid cancer, FAP: Insulin-mediated adipogenesis, FLT3 in AML, BCR-ABL in AML, miRNA in AML, PI3K/AKT, KIT in AML, mTOR in cancer
Inhibitors N-[3-[[5-bromo-4-[2-(1H-imidazol-5-yl)ethylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide; PHT-427; OSU-03012
Function Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation RPS6K 0.14
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:PI3K/AKT
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.3
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:AMPK Signaling, MTOR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP2K2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA3 0.42
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PDPK1 0.44
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, miRNA in AML, AMPK Signaling, EGFR, FAP: Insulin-mediated adipogenesis, Glioblastoma Multiforme, Insulin Receptor, Luminal Breast Cancer, mTOR in cancer, Malignant Melanoma, MTOR Signaling, IGF and Myogenesis, Non-small-cell lung cancer (NSCLC), Prostate Cancer, PI3K/AKT, Rhabdomyosarcoma, Thyroid cancer, T cell activation
+ down-regulates activity img/direct_inhibition.png phosphorylation PDPK1 0.38
Publications: 1 Organism: In Vitro
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, miRNA in AML, AMPK Signaling, EGFR, FAP: Insulin-mediated adipogenesis, Glioblastoma Multiforme, Insulin Receptor, Luminal Breast Cancer, mTOR in cancer, Malignant Melanoma, MTOR Signaling, IGF and Myogenesis, Non-small-cell lung cancer (NSCLC), Prostate Cancer, PI3K/AKT, Rhabdomyosarcoma, Thyroid cancer, T cell activation
+ img/unknown.png phosphorylation PDPK1 0.38
Publications: 4 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, miRNA in AML, AMPK Signaling, EGFR, FAP: Insulin-mediated adipogenesis, Glioblastoma Multiforme, Insulin Receptor, Luminal Breast Cancer, mTOR in cancer, Malignant Melanoma, MTOR Signaling, IGF and Myogenesis, Non-small-cell lung cancer (NSCLC), Prostate Cancer, PI3K/AKT, Rhabdomyosarcoma, Thyroid cancer, T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KB2 0.23
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SGK2 0.2
Publications: 2
+ up-regulates activity img/direct-activation.png phosphorylation SGK1 0.48
Publications: 2 Organism: In Vitro
Pathways:Insulin Receptor
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.71
Publications: 5 Organism: Homo Sapiens
Tissue: Brain
Pathways:Adipogenesis, Glioblastoma Multiforme, IGF and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation AKT2 0.42
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ up-regulates activity img/direct-activation.png phosphorylation SGK3 0.23
Publications: 2
+ down-regulates activity img/direct_inhibition.png phosphorylation AHCYL1 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation RPS6KB2 0.23
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KB1 0.34
Publications: 1 Organism: In Vitro
Pathways:MTOR Signaling
+ up-regulates img/direct-activation.png phosphorylation RPS6KB1 0.34
Publications: 4 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ up-regulates img/direct-activation.png phosphorylation SGK1 0.48
Publications: 3 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:Insulin Receptor
+ up-regulates img/direct-activation.png phosphorylation AKT3 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.47
Publications: 2 Organism: , Homo Sapiens
Pathways:Adipogenesis, Glioblastoma Multiforme, IGF and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation AKT 0.49
Publications: 5 Organism: Rattus Norvegicus, Homo Sapiens, Mus Musculus
Tissue: Brain, Muscle, Skeletal Muscle, Myotube
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, AMPK Signaling, EGFR, FAP: Insulin-mediated adipogenesis, Insulin Receptor, Luminal Breast Cancer, mTOR in cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, PI3K/AKT, Rhabdomyosarcoma, Thyroid cancer, T cell activation
+ up-regulates img/direct-activation.png phosphorylation SGK3 0.43
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCZ 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PAK1 0.44
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:EGFR, T cell activation
+ up-regulates img/direct-activation.png phosphorylation PRKCB 0.28
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRKCD 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCE 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PKN1 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ITGB3 0.22
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PKN2 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PDPK1 0.4
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
Pathways:EGFR, Rhabdomyosarcoma
+ up-regulates img/direct-activation.png phosphorylation PDPK1 0.2
Publications: 4 Organism: Homo Sapiens, In Vitro
Pathways:IGF and Myogenesis, Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png phosphorylation PDPK1 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png phosphorylation PDPK1 0.22
Publications: 1 Organism: Cricetulus Griseus
Pathways:Thyroid cancer
+ up-regulates img/direct-activation.png phosphorylation PRKCQ 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PDPK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLK1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PDPK1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SGK2 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PDPK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCA 0.3
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ down-regulates img/direct_inhibition.png chemical inhibition PDPK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization, binding PDPK1 0.72
Publications: 4 Organism: Chlorocebus Aethiops, In Vitro, Homo Sapiens
Pathways:Non-small-cell lung cancer (NSCLC)
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PDPK1 0.14
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png chemical inhibition PDPK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MEK1/2 0.35
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, EGFR, Glioblastoma Multiforme, Insulin Receptor, Luminal Breast Cancer, Malignant Melanoma, PI3K/AKT, Rhabdomyosarcoma, Thyroid cancer, T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation MEK1/2 0.35
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, EGFR, Glioblastoma Multiforme, Insulin Receptor, Luminal Breast Cancer, Malignant Melanoma, PI3K/AKT, Rhabdomyosarcoma, Thyroid cancer, T cell activation
+ up-regulates img/direct-activation.png binding PDPK1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCG 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CARD11 0.28
Publications: 1 Organism: Homo Sapiens