| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | PDPK1 | Tyr376 | DEDCYGNyDNLLSQF | phosphorylation up-regulates | 20643654 | SIGNOR-166722 |
| IGF1R | PDPK1 | Tyr376 | DEDCYGNyDNLLSQF | phosphorylation up-regulates | 20643654 | SIGNOR-166714 |
| IGF1R | PDPK1 | Tyr376 | DEDCYGNyDNLLSQF | phosphorylation up-regulates | 20044479 | SIGNOR-236544 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | PDPK1 PTyr376 | phosphorylation up-regulates → | PDPK1 | 20643654 | SIGNOR-166722 |
| IGF1R | phosphorylation up-regulates → | PDPK1 PTyr376 | phosphorylation up-regulates → | PDPK1 | 20643654 | SIGNOR-166714 |
| IGF1R | phosphorylation up-regulates → | PDPK1 PTyr376 | phosphorylation up-regulates → | PDPK1 | 20044479 | SIGNOR-236544 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → up-regulates | PDPK1 | SIGNOR-166722 |
| IGF1R | phosphorylation → up-regulates | PDPK1 | SIGNOR-166714 |
| IGF1R | phosphorylation → up-regulates | PDPK1 | SIGNOR-236544 |
