| Name | MAP3K7 |
| ID | O43318 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 36-291 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K7 | MAP2K7 | – | phosphorylation up-regulates activity | 17110930 | SIGNOR-274146 | |
| MAP3K7 | MAP2K7 | – | phosphorylation up-regulates activity | 21552290 | SIGNOR-279214 | |
| MAP3K7 | IKBKB | Ser177 | AKELDQGsLCTSFVG | phosphorylation up-regulates activity | 11460167 | SIGNOR-109490 |
| MAP3K7 | IKBKB | Ser181 | DQGSLCTsFVGTLQY | phosphorylation up-regulates activity | 11460167 | SIGNOR-109494 |
| MAP3K7 | IKBKB | – | phosphorylation up-regulates activity | 19632174 | SIGNOR-187242 | |
| MAP3K7 | MAP3K7 | Ser192 | HMTNNKGsAAWMAPE | phosphorylation up-regulates activity | 10702308 | SIGNOR-235758 |
| MAP3K7 | MAP3K7 | Ser192 | HMTNNKGsAAWMAPE | phosphorylation up-regulates activity | 20538596 | SIGNOR-232153 |
| MAP3K7 | MAP3K7 | Thr178 | LKICDFGtACDIQTH | phosphorylation up-regulates activity | 20538596 | SIGNOR-227536 |
| MAP3K7 | MAP3K7 | Thr184 | GTACDIQtHMTNNKG | phosphorylation up-regulates activity | 20538596 | SIGNOR-227544 |
| MAP3K7 | MAP3K7 | Thr187 | CDIQTHMtNNKGSAA | phosphorylation up-regulates activity | 20538596 | SIGNOR-227540 |
| MAP3K7 | RASSF9 | Ser284 | RILIDKLsAEIEKEV | phosphorylation up-regulates activity | 33717835 | SIGNOR-279534 |
| MAP3K7 | PTPN3 | Ser359 | PAMRRSLsVEHLETK | phosphorylation unknown | 9341175 | SIGNOR-52781 |
| MAP3K7 | MAP2K4 | – | phosphorylation up-regulates activity | 9278437 | SIGNOR-50618 | |
| MAP3K7 | MAP2K3 | – | phosphorylation up-regulates activity | 17299140 | SIGNOR-42402 | |
| MAP3K7 | MAP2K3 | – | phosphorylation up-regulates activity | 21902831 | SIGNOR-236093 | |
| MAP3K7 | YAP1 | Ser127 | PQHVRAHsSPASLQL | phosphorylation down-regulates activity | 30385786 | SIGNOR-278956 |
| MAP3K7 | MAP2K6 | – | phosphorylation up-regulates activity | 11460167 | SIGNOR-109497 | |
| MAP3K7 | MAP2K6 | – | phosphorylation up-regulates activity | 21902831 | SIGNOR-236145 | |
| MAP3K7 | RCAN1 | – | phosphorylation up-regulates activity | 19136967 | SIGNOR-279535 | |
| MAP3K7 | RAB8A | Thr72 | AGQERFRtITTAYYR | phosphorylation up-regulates activity | 32227113 | SIGNOR-260266 |
| MAP3K7 | RAB1A | Thr75 | AGQERFRtITSSYYR | phosphorylation up-regulates activity | 27482120 | SIGNOR-277270 |
| MAP3K7 | NFKBIB | – | phosphorylation down-regulates | 9480845 | SIGNOR-55719 | |
| MAP3K7 | TAB1 | Ser452 | STNTHTQsSSSSSDG | phosphorylation up-regulates activity | 22216226 | SIGNOR-276364 |
| MAP3K7 | TAB1 | Ser453 | TNTHTQSsSSSSDGG | phosphorylation up-regulates activity | 22216226 | SIGNOR-276366 |
| MAP3K7 | TAB1 | Ser456 | HTQSSSSsSDGGLFR | phosphorylation up-regulates activity | 22216226 | SIGNOR-276365 |
| MAP3K7 | TAB1 | Ser457 | TQSSSSSsDGGLFRS | phosphorylation up-regulates activity | 22216226 | SIGNOR-276367 |
| MAP3K7 | SMAD1 | Ser463 | SPHNPISsVS | phosphorylation up-regulates activity | 19536134 | SIGNOR-279419 |
| MAP3K7 | SMAD1 | Ser465 | HNPISSVs | phosphorylation up-regulates activity | 19536134 | SIGNOR-279420 |
| MAP3K7 | ATAT1 | Ser237 | GDIKPYSsSDREFLK | phosphorylation up-regulates activity | 29703898 | SIGNOR-272243 |
| MAP3K7 | TNFAIP8L2 | Ser3 | sFSSKSLA | phosphorylation down-regulates quantity by destabilization | 32188758 | SIGNOR-273668 |
| MAP3K7 | STING1 | Ser355 | TSAVPSTsTMSQEPE | phosphorylation up-regulates activity | 37832545 | SIGNOR-277887 |
| MAP3K7 | KSR1 | Ser406 | TRLRRTEsVPSDINN | phosphorylation down-regulates | 11741534 | SIGNOR-112779 |
| MAP3K7 | HDAC7 | Ser155 | FPLRKTVsEPNLKLR | phosphorylation down-regulates | 16980613 | SIGNOR-149579 |
| MAP3K7 | MAP3K14 | – | phosphorylation up-regulates activity | 10094049 | SIGNOR-262833 | |
| MAP3K7 | NLK | – | phosphorylation up-regulates | 12482967 | SIGNOR-96425 | |
| MAP3K7 | RIPK3 | – | phosphorylation up-regulates activity | 24535827 | SIGNOR-279634 | |
| MAP3K7 | IKK-complex | – | phosphorylation up-regulates | 11460167 | SIGNOR-217445 | |
| MAP3K7 | IKK-complex | – | phosphorylation up-regulates activity | 21133840 | SIGNOR-256024 | |
| MAP3K7 | IKK-complex | – | phosphorylation up-regulates activity | 21232017 | SIGNOR-209759 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K7 | phosphorylation up-regulates → | IKBKB PSer177 | phosphorylation up-regulates → | IKBKB | 11460167 | SIGNOR-109490 |
| MAP3K7 | phosphorylation up-regulates → | IKBKB PSer181 | phosphorylation up-regulates → | IKBKB | 11460167 | SIGNOR-109494 |
| MAP3K7 | phosphorylation up-regulates → | MAP3K7 PSer192 | phosphorylation up-regulates → | MAP3K7 | 10702308 | SIGNOR-235758 |
| MAP3K7 | phosphorylation up-regulates → | MAP3K7 PSer192 | phosphorylation up-regulates → | MAP3K7 | 20538596 | SIGNOR-232153 |
| MAP3K7 | phosphorylation up-regulates → | MAP3K7 PThr178 | phosphorylation up-regulates → | MAP3K7 | 20538596 | SIGNOR-227536 |
| MAP3K7 | phosphorylation up-regulates → | MAP3K7 PThr184 | phosphorylation up-regulates → | MAP3K7 | 20538596 | SIGNOR-227544 |
| MAP3K7 | phosphorylation up-regulates → | MAP3K7 PThr187 | phosphorylation up-regulates → | MAP3K7 | 20538596 | SIGNOR-227540 |
| MAP3K7 | phosphorylation up-regulates → | RASSF9 PSer284 | phosphorylation up-regulates → | RASSF9 | 33717835 | SIGNOR-279534 |
| MAP3K7 | phosphorylation up-regulates → | PTPN3 PSer359 | phosphorylation down-regulates ⊣ | PTPN3 | 9341175 | SIGNOR-52781 |
| MAP3K7 | phosphorylation up-regulates → | YAP1 PSer127 | phosphorylation down-regulates ⊣ | YAP1 | 30385786 | SIGNOR-278956 |
| MAP3K7 | phosphorylation up-regulates → | RAB8A PThr72 | phosphorylation up-regulates → | RAB8A | 32227113 | SIGNOR-260266 |
| MAP3K7 | phosphorylation up-regulates → | RAB1A PThr75 | phosphorylation up-regulates → | RAB1A | 27482120 | SIGNOR-277270 |
| MAP3K7 | phosphorylation up-regulates → | TAB1 PSer452 | phosphorylation up-regulates → | TAB1 | 22216226 | SIGNOR-276364 |
| MAP3K7 | phosphorylation up-regulates → | TAB1 PSer453 | phosphorylation up-regulates → | TAB1 | 22216226 | SIGNOR-276366 |
| MAP3K7 | phosphorylation up-regulates → | TAB1 PSer456 | phosphorylation up-regulates → | TAB1 | 22216226 | SIGNOR-276365 |
| MAP3K7 | phosphorylation up-regulates → | TAB1 PSer457 | phosphorylation up-regulates → | TAB1 | 22216226 | SIGNOR-276367 |
| MAP3K7 | phosphorylation up-regulates → | SMAD1 PSer463 | phosphorylation up-regulates → | SMAD1 | 19536134 | SIGNOR-279419 |
| MAP3K7 | phosphorylation up-regulates → | SMAD1 PSer465 | phosphorylation up-regulates → | SMAD1 | 19536134 | SIGNOR-279420 |
| MAP3K7 | phosphorylation up-regulates → | ATAT1 PSer237 | phosphorylation up-regulates → | ATAT1 | 29703898 | SIGNOR-272243 |
| MAP3K7 | phosphorylation up-regulates → | TNFAIP8L2 PSer3 | phosphorylation down-regulates ⊣ | TNFAIP8L2 | 32188758 | SIGNOR-273668 |
| MAP3K7 | phosphorylation up-regulates → | STING1 PSer355 | phosphorylation up-regulates → | STING1 | 37832545 | SIGNOR-277887 |
| MAP3K7 | phosphorylation up-regulates → | KSR1 PSer406 | phosphorylation down-regulates ⊣ | KSR1 | 11741534 | SIGNOR-112779 |
| MAP3K7 | phosphorylation up-regulates → | HDAC7 PSer155 | phosphorylation down-regulates ⊣ | HDAC7 | 16980613 | SIGNOR-149579 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP3K7 | phosphorylation → up-regulates activity | MAP2K7 | SIGNOR-274146 |
| MAP3K7 | phosphorylation → up-regulates activity | MAP2K7 | SIGNOR-279214 |
| MAP3K7 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-109490 |
| MAP3K7 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-109494 |
| MAP3K7 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-187242 |
| MAP3K7 | phosphorylation → up-regulates activity | MAP3K7 | SIGNOR-235758 |
| MAP3K7 | phosphorylation → up-regulates activity | MAP3K7 | SIGNOR-232153 |
| MAP3K7 | phosphorylation → up-regulates activity | MAP3K7 | SIGNOR-227536 |
| MAP3K7 | phosphorylation → up-regulates activity | MAP3K7 | SIGNOR-227544 |
| MAP3K7 | phosphorylation → up-regulates activity | MAP3K7 | SIGNOR-227540 |
| MAP3K7 | phosphorylation → up-regulates activity | RASSF9 | SIGNOR-279534 |
| MAP3K7 | phosphorylation → unknown | PTPN3 | SIGNOR-52781 |
| MAP3K7 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-50618 |
| MAP3K7 | phosphorylation → up-regulates activity | MAP2K3 | SIGNOR-42402 |
| MAP3K7 | phosphorylation → up-regulates activity | MAP2K3 | SIGNOR-236093 |
| MAP3K7 | phosphorylation → down-regulates activity | YAP1 | SIGNOR-278956 |
| MAP3K7 | phosphorylation → up-regulates activity | MAP2K6 | SIGNOR-109497 |
| MAP3K7 | phosphorylation → up-regulates activity | MAP2K6 | SIGNOR-236145 |
| MAP3K7 | phosphorylation → up-regulates activity | RCAN1 | SIGNOR-279535 |
| MAP3K7 | phosphorylation → up-regulates activity | RAB8A | SIGNOR-260266 |
| MAP3K7 | phosphorylation → up-regulates activity | RAB1A | SIGNOR-277270 |
| MAP3K7 | phosphorylation down-regulates | NFKBIB | SIGNOR-55719 |
| MAP3K7 | phosphorylation → up-regulates activity | TAB1 | SIGNOR-276364 |
| MAP3K7 | phosphorylation → up-regulates activity | TAB1 | SIGNOR-276366 |
| MAP3K7 | phosphorylation → up-regulates activity | TAB1 | SIGNOR-276365 |
| MAP3K7 | phosphorylation → up-regulates activity | TAB1 | SIGNOR-276367 |
| MAP3K7 | phosphorylation → up-regulates activity | SMAD1 | SIGNOR-279419 |
| MAP3K7 | phosphorylation → up-regulates activity | SMAD1 | SIGNOR-279420 |
| MAP3K7 | phosphorylation → up-regulates activity | ATAT1 | SIGNOR-272243 |
| MAP3K7 | phosphorylation down-regulates quantity by destabilization | TNFAIP8L2 | SIGNOR-273668 |
| MAP3K7 | phosphorylation → up-regulates activity | STING1 | SIGNOR-277887 |
| MAP3K7 | phosphorylation down-regulates | KSR1 | SIGNOR-112779 |
| MAP3K7 | phosphorylation down-regulates | HDAC7 | SIGNOR-149579 |
| MAP3K7 | phosphorylation → up-regulates activity | MAP3K14 | SIGNOR-262833 |
| MAP3K7 | phosphorylation → up-regulates | NLK | SIGNOR-96425 |
| MAP3K7 | phosphorylation → up-regulates activity | RIPK3 | SIGNOR-279634 |
| MAP3K7 | phosphorylation → up-regulates | IKK-complex | SIGNOR-217445 |
| MAP3K7 | phosphorylation → up-regulates activity | IKK-complex | SIGNOR-256024 |
| MAP3K7 | phosphorylation → up-regulates activity | IKK-complex | SIGNOR-209759 |