Summary

Name MAP3K7
Full Name Mitogen-activated protein kinase kinase kinase 7
Synonyms Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1 | TAK1
Primary ID O43318
Links - -
Type protein
Relations 47
Pathways Toll like receptors, IL1 Receptor, NF-KB Canonical, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, TGFbeta Signaling, Inhibition of Apoptosis
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination MAP3K7 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, SAPK/JNK Signaling
+ up-regulates activity img/direct-activation.png ubiquitination MAP3K7 0.77
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Receptor, NF-KB Canonical, P38 Signaling, TGFbeta Signaling, Toll like receptors
+ down-regulates img/direct_inhibition.png phosphorylation HDAC7 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IKBKB 0.5
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K7 0.44
Publications: 5 Organism: Homo Sapiens, In Vitro
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, TGFbeta Signaling, Toll like receptors
+ img/unknown.png phosphorylation PTPN3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KSR1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAP3K7 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAP3K7 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAP3K7 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png phosphorylation MAP3K7 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation NFKBIB 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NLK 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IKK-complex 0.44
Publications: 2 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ up-regulates activity img/direct-activation.png binding MAP3K7 0.62
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates activity img/direct-activation.png binding IKBKG 0.53
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ up-regulates img/direct-activation.png phosphorylation IKK-complex 0.44
Publications: 2 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K6 0.62
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, TGFbeta Signaling, Toll like receptors
+ up-regulates activity img/indirect-activation.png MAP3K4 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates activity img/direct-activation.png binding MAP3K7 0.6
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Canonical
+ down-regulates activity img/direct_inhibition.png binding MAP3K7 0.22
Publications: 1 Organism: Rattus Norvegicus
Pathways:TGFbeta Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K4 0.3
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, TGFbeta Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K3 0.6
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TGFbeta Signaling, Toll like receptors
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFKB1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png binding MAP3K7 0.14
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
+ img/unknown.png binding MAP3K7 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding MAP3K7 0.81
Publications: 3 Organism: Homo Sapiens
Pathways:IL1 Receptor, NF-KB Canonical, P38 Signaling and Myogenesis
+ down-regulates quantity by destabilization img/indirect_inhibition.png NFKBIA 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ up-regulates img/indirect-activation.png MAP3K7 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates img/direct-activation.png binding MAP3K7 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png binding MAP3K7 0.14
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation MAP3K7 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png NfKb-p65/p50 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ up-regulates activity img/direct-activation.png binding MAP3K7 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Canonical, P38 Signaling and Myogenesis, SAPK/JNK Signaling