Summary

Name MAP3K7
Full Name Mitogen-activated protein kinase kinase kinase 7
Synonyms Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1 | TAK1
Primary ID O43318
Links - -
Type protein
Relations 53
Pathways COVID-19 Causal Network, EBV infection, FAP: BMP, FAP: TGF beta, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, Macrophage: IL1 beta, Macrophage: TNF alpha, NF-KB Canonical, Osteoblast: BMP, Osteoblast: TGF beta, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, Satellite: IL1 , SARS-CoV INFLAMMATORY RESPONSE, TGF-beta Signaling, Toll like receptors
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity. Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination MAP3K7 0.575
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, P38 Signaling, SAPK/JNK Signaling
+ up-regulates activity img/direct-activation.png polyubiquitination MAP3K7 0.349
Publications: 1
+ up-regulates activity img/direct-activation.png ubiquitination MAP3K7 0.887
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, NF-KB Canonical, P38 Signaling, SARS-CoV MAPK PERTURBATION, SARS-CoV INFLAMMATORY RESPONSE, TGF-beta Signaling, Toll like receptors
+ down-regulates img/direct_inhibition.png phosphorylation HDAC7 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IKBKB 0.74
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K7 0.2
Publications: 5 Organism: Homo Sapiens, In Vitro
Pathways:COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, NF-KB Canonical, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, SARS-CoV INFLAMMATORY RESPONSE, TGF-beta Signaling, Toll like receptors
+ up-regulates activity img/direct-activation.png phosphorylation ATAT1 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TNFAIP8L2 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTPN3 0.267
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KSR1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAP3K7 0.379
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAP3K7 0.379
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAP3K7 0.334
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ up-regulates activity img/direct-activation.png phosphorylation RAB8A 0.254
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding MAP3K7 0.933
Publications: 3 Organism: Homo Sapiens
Pathways:IL1 Signaling , NF-KB Canonical, P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding MAP3K7 0.926
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation NLK 0.631
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAP3K7 0.531
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, SAPK/JNK Signaling
+ up-regulates activity img/direct-activation.png deubiquitination MAP3K7 0.617
Publications: 1 Organism: Mus Musculus
Pathways:NF-KB Canonical
+ up-regulates img/direct-activation.png binding MAP3K7 0.559
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K6 0.748
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling, Toll like receptors
+ up-regulates activity img/indirect-activation.png NfKb-p65/p50 0.637
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, NF-KB Canonical, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors
+ up-regulates activity img/indirect-activation.png MAP3K7 0.381
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation NFKBIB 0.49
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IKK-complex 0.713
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, NF-KB Canonical, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors
+ up-regulates activity img/direct-activation.png phosphorylation IKK-complex 0.713
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, NF-KB Canonical, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors
+ up-regulates activity img/direct-activation.png binding MAP3K7 0.824
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Canonical
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K3 0.48
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Pathways:COVID-19 Causal Network, P38 Signaling, P38 Signaling and Myogenesis, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling, Toll like receptors
+ down-regulates quantity by destabilization img/indirect_inhibition.png NFKBIA 0.655
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ down-regulates activity img/direct_inhibition.png binding MAP3K7 0.546
Publications: 1 Organism: Rattus Norvegicus
Pathways:TGF-beta Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K14 0.539
Publications: 1
+ up-regulates activity img/indirect-activation.png MAP3K4 0.301
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ img/unknown.png binding MAP3K7 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding IKBKG 0.804
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K4 0.692
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling
+ up-regulates activity img/direct-activation.png binding MAP3K7 0.528
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Inflammosome Activation, NF-KB Canonical, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV INFLAMMATORY RESPONSE
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFKB1 0.58
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K7 0.625
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Toll like receptors
+ img/unknown.png binding MAP3K7 0.2
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
+ img/unknown.png binding MAP3K7 0.2
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation MAP3K7 0.2
Publications: 1 Organism: Homo Sapiens