Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
AKT	HTRA2	Ser212 View in OncoXplorer	RVRVRLLsGDTYEAV	phosphorylation down-regulates	17311912	SIGNOR-153323
AKT1	HTRA2	Ser212 View in OncoXplorer	RVRVRLLsGDTYEAV	phosphorylation down-regulates	17311912	SIGNOR-252500
PINK1	HTRA2	Ser142	VPSPPPAsPRSQYNF	phosphorylation up-regulates	17906618	SIGNOR-158052
CDK5	HTRA2	Ser400	IHKVILGsPAHRAGL	phosphorylation up-regulates	21701498	SIGNOR-174598
AKT2	HTRA2	Ser212 View in OncoXplorer	RVRVRLLsGDTYEAV	phosphorylation down-regulates	17311912	SIGNOR-153327

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
AKT	phosphorylation up-regulates →	HTRA2 PSer212	phosphorylation down-regulates ⊣	HTRA2	17311912	SIGNOR-153323
AKT1	phosphorylation up-regulates →	HTRA2 PSer212	phosphorylation down-regulates ⊣	HTRA2	17311912	SIGNOR-252500
PINK1	phosphorylation up-regulates →	HTRA2 PSer142	phosphorylation up-regulates →	HTRA2	17906618	SIGNOR-158052
CDK5	phosphorylation up-regulates →	HTRA2 PSer400	phosphorylation up-regulates →	HTRA2	21701498	SIGNOR-174598
AKT2	phosphorylation up-regulates →	HTRA2 PSer212	phosphorylation down-regulates ⊣	HTRA2	17311912	SIGNOR-153327

Regulator	Mechanism/Effect	Target	SIGNOR-ID
AKT	phosphorylation down-regulates	HTRA2	SIGNOR-153323
AKT1	phosphorylation down-regulates	HTRA2	SIGNOR-252500
PINK1	phosphorylation → up-regulates	HTRA2	SIGNOR-158052
CDK5	phosphorylation → up-regulates	HTRA2	SIGNOR-174598
AKT2	phosphorylation down-regulates	HTRA2	SIGNOR-153327