4.0
Summary
| Name |  HTRA2View Modifications |
| Full Name | Serine protease HTRA2, mitochondrial |
| Synonyms | High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI | OMI, PRSS25 |
| Primary ID | O43464 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Pathways | Parkinson |
| Function | Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PINK1 | up-regulates 
phosphorylation
|
HTRA2 | 0.607 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Parkinson | |||
| + | AKT2 | down-regulates 
phosphorylation
|
HTRA2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT | down-regulates
phosphorylation
|
HTRA2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 | down-regulates
phosphorylation
|
HTRA2 | 0.322 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Parkinson | |||
| + | CDK5 | up-regulates
phosphorylation
|
HTRA2 | 0.456 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AREL1 | down-regulates quantity by destabilization
ubiquitination
|
HTRA2 | 0.406 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BCL2 | down-regulates 
|
HTRA2 | 0.251 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HTRA2 | down-regulates
binding
|
PEA15 | 0.485 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BAX | up-regulates
relocalization
|
HTRA2 | 0.313 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BAK1 | up-regulates
relocalization
|
HTRA2 | 0.295 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HTRA2 | down-regulates
binding
|
XIAP | 0.709 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Parkinson | |||
| + | BAK1 | up-regulates 
|
HTRA2 | 0.295 |
| Publications: | 1 | Organism: | Homo Sapiens | |