| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | HTRA2 | Ser212 | RVRVRLLsGDTYEAV | phosphorylation down-regulates | 17311912 | SIGNOR-153327 |
| AKT | HTRA2 | Ser212 | RVRVRLLsGDTYEAV | phosphorylation down-regulates | 17311912 | SIGNOR-153323 |
| AKT1 | HTRA2 | Ser212 | RVRVRLLsGDTYEAV | phosphorylation down-regulates | 17311912 | SIGNOR-252500 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | phosphorylation up-regulates → | HTRA2 PSer212 | phosphorylation down-regulates ⊣ | HTRA2 | 17311912 | SIGNOR-153327 |
| AKT | phosphorylation up-regulates → | HTRA2 PSer212 | phosphorylation down-regulates ⊣ | HTRA2 | 17311912 | SIGNOR-153323 |
| AKT1 | phosphorylation up-regulates → | HTRA2 PSer212 | phosphorylation down-regulates ⊣ | HTRA2 | 17311912 | SIGNOR-252500 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT2 | phosphorylation![]() down-regulates | HTRA2 | SIGNOR-153327 |
| AKT | phosphorylation![]() down-regulates | HTRA2 | SIGNOR-153323 |
| AKT1 | phosphorylation![]() down-regulates | HTRA2 | SIGNOR-252500 |