| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN2 | BCL2L11 | – | dephosphorylation up-regulates activity | 21984578 | SIGNOR-277055 | |
| MAPK9 | BCL2L11 | Ser77 | PGPFATRsPLFIFMR | phosphorylation up-regulates activity | 12818176 | SIGNOR-250135 |
| MAPK10 | BCL2L11 | Ser77 | PGPFATRsPLFIFMR | phosphorylation up-regulates activity | 12818176 | SIGNOR-250131 |
| MAPK1 | BCL2L11 | – | phosphorylation down-regulates quantity by destabilization | 16282323 | SIGNOR-141584 | |
| MAPK10 | BCL2L11 | Ser69 | GPLAPPAsPGPFATR | phosphorylation down-regulates quantity by destabilization | 15486195 | SIGNOR-250080 |
| MAPK10 | BCL2L11 | Thr116 | SCDKSTQtPSPPCQA | phosphorylation up-regulates | 18498746 | SIGNOR-178683 |
| MAPK1 | BCL2L11 | Ser69 | GPLAPPAsPGPFATR | phosphorylation down-regulates quantity by destabilization | 15486195 | SIGNOR-129874 |
| JNK | BCL2L11 | Ser118 | DKSTQTPsPPCQAFN | phosphorylation up-regulates | 12591950 | SIGNOR-98388 |
| AKT1 | BCL2L11 | Ser87 | FIFMRRSsLLSRSSS | phosphorylation down-regulates activity | 16282323 | SIGNOR-252487 |
| MAPK8 | BCL2L11 | – | phosphorylation up-regulates | 18498746 | SIGNOR-178686 | |
| Gbeta | BCL2L11 | – | phosphorylation down-regulates quantity by destabilization | 15486195 | SIGNOR-270031 | |
| ERK1/2 | BCL2L11 | – | phosphorylation down-regulates quantity by destabilization | 15486195 | SIGNOR-270152 | |
| MAPK3 | BCL2L11 | Ser69 | GPLAPPAsPGPFATR | phosphorylation down-regulates quantity by destabilization | 15486195 | SIGNOR-129878 |
| MAPK8 | BCL2L11 | Ser69 | GPLAPPAsPGPFATR | phosphorylation down-regulates quantity by destabilization | 18174237 | SIGNOR-160323 |
| JNK | BCL2L11 | Thr116 | SCDKSTQtPSPPCQA | phosphorylation up-regulates | 12591950 | SIGNOR-98392 |
| MAPK9 | BCL2L11 | Ser69 | GPLAPPAsPGPFATR | phosphorylation down-regulates quantity by destabilization | 18174237 | SIGNOR-250136 |
| AURKA | BCL2L11 | Ser94 | SLLSRSSsGYFSFDT | phosphorylation down-regulates quantity by destabilization | 23912711 | SIGNOR-276248 |
| JNK | BCL2L11 | Ser104 | FSFDTDRsPAPMSCD | phosphorylation up-regulates | 12591950 | SIGNOR-98384 |
| MAPK8 | BCL2L11 | Ser69 | GPLAPPAsPGPFATR | phosphorylation down-regulates quantity by destabilization | 15486195 | SIGNOR-250132 |
| p38 | BCL2L11 | Ser69 | GPLAPPAsPGPFATR | phosphorylation down-regulates quantity by destabilization | 15486195 | SIGNOR-260443 |
| AKT | BCL2L11 | Ser87 | FIFMRRSsLLSRSSS | phosphorylation down-regulates activity | 16282323 | SIGNOR-141581 |
| MAPK8 | BCL2L11 | Thr116 | SCDKSTQtPSPPCQA | phosphorylation up-regulates | 12591950 | SIGNOR-98396 |
| AURKA | BCL2L11 | Ser93 | SSLLSRSsSGYFSFD | phosphorylation down-regulates quantity by destabilization | 23912711 | SIGNOR-276247 |
| CDK1 | BCL2L11 | Ser104 | FSFDTDRsPAPMSCD | phosphorylation up-regulates activity | 22071694 | SIGNOR-267985 |
| MAPK8 | BCL2L11 | Ser77 | PGPFATRsPLFIFMR | phosphorylation up-regulates activity | 12818176 | SIGNOR-250133 |
| AURKA | BCL2L11 | Ser98 | RSSSGYFsFDTDRSP | phosphorylation down-regulates quantity by destabilization | 23912711 | SIGNOR-276246 |
| MAPK8 | BCL2L11 | – | phosphorylation down-regulates | 18174237 | SIGNOR-160326 | |
| MAPK8 | BCL2L11 | – | phosphorylation up-regulates | 12591950 | SIGNOR-98399 | |
| MAPK9 | BCL2L11 | Ser59 | GDSCPHGsPQGPLAP | phosphorylation up-regulates activity | 12818176 | SIGNOR-250134 |
| MAPK14 | BCL2L11 | Ser69 | GPLAPPAsPGPFATR | phosphorylation down-regulates quantity by destabilization | 15486195 | SIGNOR-260442 |
| MAPK10 | BCL2L11 | Ser59 | GDSCPHGsPQGPLAP | phosphorylation up-regulates activity | 12818176 | SIGNOR-250130 |
| AURKA | BCL2L11 | – | phosphorylation down-regulates quantity | 23912711 | SIGNOR-279009 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK9 | phosphorylation up-regulates → | BCL2L11 PSer77 | phosphorylation up-regulates → | BCL2L11 | 12818176 | SIGNOR-250135 |
| MAPK10 | phosphorylation up-regulates → | BCL2L11 PSer77 | phosphorylation up-regulates → | BCL2L11 | 12818176 | SIGNOR-250131 |
| MAPK10 | phosphorylation up-regulates → | BCL2L11 PSer69 | phosphorylation down-regulates ⊣ | BCL2L11 | 15486195 | SIGNOR-250080 |
| MAPK10 | phosphorylation up-regulates → | BCL2L11 PThr116 | phosphorylation up-regulates → | BCL2L11 | 18498746 | SIGNOR-178683 |
| MAPK1 | phosphorylation up-regulates → | BCL2L11 PSer69 | phosphorylation down-regulates ⊣ | BCL2L11 | 15486195 | SIGNOR-129874 |
| JNK | phosphorylation up-regulates → | BCL2L11 PSer118 | phosphorylation up-regulates → | BCL2L11 | 12591950 | SIGNOR-98388 |
| AKT1 | phosphorylation up-regulates → | BCL2L11 PSer87 | phosphorylation down-regulates ⊣ | BCL2L11 | 16282323 | SIGNOR-252487 |
| MAPK3 | phosphorylation up-regulates → | BCL2L11 PSer69 | phosphorylation down-regulates ⊣ | BCL2L11 | 15486195 | SIGNOR-129878 |
| MAPK8 | phosphorylation up-regulates → | BCL2L11 PSer69 | phosphorylation down-regulates ⊣ | BCL2L11 | 18174237 | SIGNOR-160323 |
| JNK | phosphorylation up-regulates → | BCL2L11 PThr116 | phosphorylation up-regulates → | BCL2L11 | 12591950 | SIGNOR-98392 |
| MAPK9 | phosphorylation up-regulates → | BCL2L11 PSer69 | phosphorylation down-regulates ⊣ | BCL2L11 | 18174237 | SIGNOR-250136 |
| AURKA | phosphorylation up-regulates → | BCL2L11 PSer94 | phosphorylation down-regulates ⊣ | BCL2L11 | 23912711 | SIGNOR-276248 |
| JNK | phosphorylation up-regulates → | BCL2L11 PSer104 | phosphorylation up-regulates → | BCL2L11 | 12591950 | SIGNOR-98384 |
| MAPK8 | phosphorylation up-regulates → | BCL2L11 PSer69 | phosphorylation down-regulates ⊣ | BCL2L11 | 15486195 | SIGNOR-250132 |
| p38 | phosphorylation up-regulates → | BCL2L11 PSer69 | phosphorylation down-regulates ⊣ | BCL2L11 | 15486195 | SIGNOR-260443 |
| AKT | phosphorylation up-regulates → | BCL2L11 PSer87 | phosphorylation down-regulates ⊣ | BCL2L11 | 16282323 | SIGNOR-141581 |
| MAPK8 | phosphorylation up-regulates → | BCL2L11 PThr116 | phosphorylation up-regulates → | BCL2L11 | 12591950 | SIGNOR-98396 |
| AURKA | phosphorylation up-regulates → | BCL2L11 PSer93 | phosphorylation down-regulates ⊣ | BCL2L11 | 23912711 | SIGNOR-276247 |
| CDK1 | phosphorylation up-regulates → | BCL2L11 PSer104 | phosphorylation up-regulates → | BCL2L11 | 22071694 | SIGNOR-267985 |
| MAPK8 | phosphorylation up-regulates → | BCL2L11 PSer77 | phosphorylation up-regulates → | BCL2L11 | 12818176 | SIGNOR-250133 |
| AURKA | phosphorylation up-regulates → | BCL2L11 PSer98 | phosphorylation down-regulates ⊣ | BCL2L11 | 23912711 | SIGNOR-276246 |
| MAPK9 | phosphorylation up-regulates → | BCL2L11 PSer59 | phosphorylation up-regulates → | BCL2L11 | 12818176 | SIGNOR-250134 |
| MAPK14 | phosphorylation up-regulates → | BCL2L11 PSer69 | phosphorylation down-regulates ⊣ | BCL2L11 | 15486195 | SIGNOR-260442 |
| MAPK10 | phosphorylation up-regulates → | BCL2L11 PSer59 | phosphorylation up-regulates → | BCL2L11 | 12818176 | SIGNOR-250130 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN2 | dephosphorylation → up-regulates activity | BCL2L11 | SIGNOR-277055 |
| MAPK9 | phosphorylation → up-regulates activity | BCL2L11 | SIGNOR-250135 |
| MAPK10 | phosphorylation → up-regulates activity | BCL2L11 | SIGNOR-250131 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-141584 |
| MAPK10 | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-250080 |
| MAPK10 | phosphorylation → up-regulates | BCL2L11 | SIGNOR-178683 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-129874 |
| JNK | phosphorylation → up-regulates | BCL2L11 | SIGNOR-98388 |
| AKT1 | phosphorylation → down-regulates activity | BCL2L11 | SIGNOR-252487 |
| MAPK8 | phosphorylation → up-regulates | BCL2L11 | SIGNOR-178686 |
| Gbeta | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-270031 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-270152 |
| MAPK3 | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-129878 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-160323 |
| JNK | phosphorylation → up-regulates | BCL2L11 | SIGNOR-98392 |
| MAPK9 | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-250136 |
| AURKA | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-276248 |
| JNK | phosphorylation → up-regulates | BCL2L11 | SIGNOR-98384 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-250132 |
| p38 | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-260443 |
| AKT | phosphorylation → down-regulates activity | BCL2L11 | SIGNOR-141581 |
| MAPK8 | phosphorylation → up-regulates | BCL2L11 | SIGNOR-98396 |
| AURKA | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-276247 |
| CDK1 | phosphorylation → up-regulates activity | BCL2L11 | SIGNOR-267985 |
| MAPK8 | phosphorylation → up-regulates activity | BCL2L11 | SIGNOR-250133 |
| AURKA | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-276246 |
| MAPK8 | phosphorylation down-regulates | BCL2L11 | SIGNOR-160326 |
| MAPK8 | phosphorylation → up-regulates | BCL2L11 | SIGNOR-98399 |
| MAPK9 | phosphorylation → up-regulates activity | BCL2L11 | SIGNOR-250134 |
| MAPK14 | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-260442 |
| MAPK10 | phosphorylation → up-regulates activity | BCL2L11 | SIGNOR-250130 |
| AURKA | phosphorylation → down-regulates quantity | BCL2L11 | SIGNOR-279009 |
