Summary

Name BCL2L11
Full Name Bcl-2-like protein 11
Synonyms Bcl2-L-11, Bcl2-interacting mediator of cell death | BIM
Primary ID O43521
Links - -
Type protein
Relations 40
Pathways Mitochondrial Control of Apoptosis, SAPK/JNK Signaling, Inhibition of Apoptosis
Function Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation BCL2L11 0.14
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BCL2L11 0.2
Publications: 2 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation BCL2L11 0.14
Publications: 3
+ down-regulates img/direct_inhibition.png phosphorylation BCL2L11 0.22
Publications: 2 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation BCL2L11 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BCL2L11 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BCL2L11 0.31
Publications: 2 Organism: Mus Musculus
Pathways:SAPK/JNK Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation BCL2L11 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation BCL2L11 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BCL2L11 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ up-regulates img/direct-activation.png phosphorylation BCL2L11 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BCL2L11 0.31
Publications: 3 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates img/direct-activation.png binding BAK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BAX 0.48
Publications: 4 Organism: Homo Sapiens, Mus Musculus
Tissue: Liver
Pathways:SAPK/JNK Signaling
+ down-regulates activity img/direct_inhibition.png binding BCL2 0.72
Publications: 2 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Mitochondrial Control of Apoptosis
+ up-regulates img/indirect-activation.png BCL2L11 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding BCL2L1 0.52
Publications: 2 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2L11 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BCL2L11 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2L11 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ up-regulates activity img/direct-activation.png binding BAK/BAX 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Mitochondrial Control of Apoptosis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2L11 0.3
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ down-regulates img/direct_inhibition.png binding BCL2 0.72
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Mitochondrial Control of Apoptosis
+ down-regulates img/direct_inhibition.png binding BCL2L1 0.52
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ down-regulates img/direct_inhibition.png binding BCL2L2 0.28
Publications: 1 Organism: Homo Sapiens