| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 15084260 | SIGNOR-124207 |
| PPP2CA | FOXO3 | Ser253 | APRRRAVsMDNSNKY | dephosphorylation up-regulates | 20110348 | SIGNOR-163680 |
| AKT2 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249641 |
| MAPK3 | FOXO3 | Ser344 | QDDDAPLsPMLYSSS | phosphorylation down-regulates quantity by destabilization | 19282669 | SIGNOR-184573 |
| AKT2 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 19188143 | SIGNOR-236671 |
| AMPK | FOXO3 | Ser588 | QTLSDSLsGSSLYST | phosphorylation up-regulates activity | 17711846 | SIGNOR-274096 |
| SGK1 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 11154281 | SIGNOR-249133 |
| AMPK | FOXO3 | Ser399 | DNITLPPsQPSPTGG | phosphorylation up-regulates activity | 17711846 | SIGNOR-274095 |
| AKT | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249647 |
| AKT3 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249643 |
| DYRK1A | FOXO3 | Ser330 | RLSPIMAsTELDEVQ | phosphorylation down-regulates activity | 19188143 | SIGNOR-106833 |
| AKT | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 19188143 | SIGNOR-183620 |
| MAPK14 | FOXO3 | Ser7 | sPAPLSPL | phosphorylation up-regulates | 22128155 | SIGNOR-177927 |
| CSNK1A1 | FOXO3 | Ser321 | NSNASTVsGRLSPIM | phosphorylation down-regulates | 20110348 | SIGNOR-163676 |
| MAPK1 | FOXO3 | Ser344 | QDDDAPLsPMLYSSS | phosphorylation down-regulates quantity by destabilization | 18204439 | SIGNOR-160411 |
| AMPK | FOXO3 | Ser399 | DNITLPPsQPSPTGG | phosphorylation up-regulates activity | 17711846 | SIGNOR-249668 |
| AKT1 | FOXO3 | – | phosphorylation down-regulates activity | 21798082 | SIGNOR-175288 | |
| AMPK | FOXO3 | Ser413 | GLMQRSSsFPYTTKG | phosphorylation up-regulates activity | 22848740 | SIGNOR-255756 |
| AMPK | FOXO3 | Ser588 | QTLSDSLsGSSLYST | phosphorylation up-regulates activity | 17711846 | SIGNOR-249685 |
| PRKAA1 | FOXO3 | Ser555 | RALSNSVsNMGLSES | phosphorylation up-regulates activity | 17711846 | SIGNOR-249681 |
| PRKAA1 | FOXO3 | Ser413 | GLMQRSSsFPYTTKG | phosphorylation up-regulates activity | 17711846 | SIGNOR-249677 |
| CSNK1A1 | FOXO3 | – | phosphorylation down-regulates | 19188143 | SIGNOR-183661 | |
| AKT1 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249627 |
| PRKAA1 | FOXO3 | – | phosphorylation up-regulates activity | 17900900 | SIGNOR-219247 | |
| CHUK | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 15084260 | SIGNOR-124203 |
| AKT | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249645 |
| AKT2 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 19188143 | SIGNOR-235960 |
| STK4 | FOXO3 | Ser209 | SSAGWKNsIRHNLSL | phosphorylation up-regulates | 18394876 | SIGNOR-178190 |
| SGK3 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 11154281 | SIGNOR-249135 |
| PRKAA1 | FOXO3 | Ser626 | SLECDMEsIIRSELM | phosphorylation up-regulates activity | 17711846 | SIGNOR-249687 |
| AKT1 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 19188143 | SIGNOR-252524 |
| IKBKE | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 23691078 | SIGNOR-202054 |
| MAPK8 | FOXO3 | Ser574 | SAKHQQQsPVSQSMQ | phosphorylation up-regulates activity | 27669435 | SIGNOR-280030 |
| IKBKB | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 19188143 | SIGNOR-183684 |
| AMPK | FOXO3 | Ser626 | SLECDMEsIIRSELM | phosphorylation up-regulates activity | 17711846 | SIGNOR-249688 |
| AKT3 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates | 19188143 | SIGNOR-183648 |
| DYRK1A | FOXO3 | Ser330 | RLSPIMAsTELDEVQ | phosphorylation down-regulates | 19188143 | SIGNOR-183674 |
| SGK1 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 11154281 | SIGNOR-236607 |
| AKT3 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249644 |
| AMPK | FOXO3 | Thr179 | SSPDKRLtLSQIYEW | phosphorylation up-regulates activity | 17711846 | SIGNOR-274094 |
| AKT1 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249626 |
| Gbeta | FOXO3 | – | phosphorylation down-regulates quantity by destabilization | 19282669 | SIGNOR-270070 | |
| AMPK | FOXO3 | Ser555 | RALSNSVsNMGLSES | phosphorylation up-regulates activity | 17711846 | SIGNOR-249682 |
| AKT3 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249642 |
| PIM1 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates | 18593906 | SIGNOR-179304 |
| IKK-complex | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 15084260 | SIGNOR-216407 |
| MELK | FOXO3 | – | phosphorylation down-regulates quantity | 28938528 | SIGNOR-279375 | |
| PPP2CA | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | dephosphorylation up-regulates | 20110348 | SIGNOR-163684 |
| MAPK1 | FOXO3 | Ser294 | QLSKWPGsPTSRSSD | phosphorylation down-regulates quantity by destabilization | 18204439 | SIGNOR-160407 |
| AKT1 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 19188143 | SIGNOR-252522 |
| ERK1/2 | FOXO3 | – | phosphorylation down-regulates quantity by destabilization | 19282669 | SIGNOR-270175 | |
| AMPK | FOXO3 | Ser555 | RALSNSVsNMGLSES | phosphorylation up-regulates activity | 17711846 | SIGNOR-274093 |
| PLK1 | FOXO3 | – | phosphorylation down-regulates activity | 26280018 | SIGNOR-279095 | |
| AKT1 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 19188143 | SIGNOR-252523 |
| AKT2 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 19188143 | SIGNOR-236675 |
| AKT2 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249640 |
| CSNK1A1 | FOXO3 | Ser318 | SRTNSNAsTVSGRLS | phosphorylation down-regulates | 20110348 | SIGNOR-163672 |
| AKT | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249646 |
| PRKAA1 | FOXO3 | – | phosphorylation up-regulates activity | 22848740 | SIGNOR-255755 | |
| PRKAA1 | FOXO3 | Ser399 | DNITLPPsQPSPTGG | phosphorylation up-regulates activity | 17711846 | SIGNOR-249667 |
| PIM | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 18593906 | SIGNOR-259428 |
| AKT | FOXO3 | – | phosphorylation down-regulates activity | 14981546 | SIGNOR-261526 | |
| AMPK | FOXO3 | Ser413 | GLMQRSSsFPYTTKG | phosphorylation up-regulates activity | 17711846 | SIGNOR-274098 |
| AKT1 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249625 |
| MAPKAPK5 | FOXO3 | Ser215 | NSIRHNLsLHSRFMR | phosphorylation up-regulates activity | 21329882 | SIGNOR-279469 |
| MAPK3 | FOXO3 | Ser425 | TKGSGLGsPTSSFNS | phosphorylation down-regulates quantity by destabilization | 19282669 | SIGNOR-184577 |
| MAPK3 | FOXO3 | Ser294 | QLSKWPGsPTSRSSD | phosphorylation down-regulates quantity by destabilization | 19282669 | SIGNOR-184569 |
| AMPK | FOXO3 | Ser413 | GLMQRSSsFPYTTKG | phosphorylation up-regulates activity | 17711846 | SIGNOR-249678 |
| IKK-complex | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates quantity by destabilization | 19188143 | SIGNOR-209769 |
| PIM1 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 18593906 | SIGNOR-179308 |
| STK4 | FOXO3 | Ser209 | SSAGWKNsIRHNLSL | phosphorylation up-regulates | 22898666 | SIGNOR-191851 |
| AMPK | FOXO3 | – | phosphorylation up-regulates activity | 17900900 | SIGNOR-216481 | |
| AKT3 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates | 19188143 | SIGNOR-183652 |
| AKT | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 19188143 | SIGNOR-183616 |
| PPP2CA | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | dephosphorylation up-regulates activity | 20110348 | SIGNOR-163688 |
| AKT2 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249639 |
| GNA13 | FOXO3 | – | phosphorylation up-regulates activity | 37392861 | SIGNOR-278050 | |
| PIM | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates | 18593906 | SIGNOR-259429 |
| SGK2 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 11154281 | SIGNOR-249130 |
| AKT | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 19188143 | SIGNOR-183612 |
| AKT3 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates | 19188143 | SIGNOR-183644 |
| SGK1 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 11154281 | SIGNOR-249134 |
| AMPK | FOXO3 | Thr179 | SSPDKRLtLSQIYEW | phosphorylation up-regulates activity | 17711846 | SIGNOR-238813 |
| AMPK | FOXO3 | Ser626 | SLECDMEsIIRSELM | phosphorylation up-regulates activity | 17711846 | SIGNOR-274097 |
| MAPK1 | FOXO3 | Ser425 | TKGSGLGsPTSSFNS | phosphorylation down-regulates quantity by destabilization | 18204439 | SIGNOR-160415 |
| CDK6 | FOXO3 | Ser325 | STVSGRLsPIMASTE | phosphorylation up-regulates activity | 28778953 | SIGNOR-279023 |
| TYRO3 | FOXO3 | – | phosphorylation down-regulates activity | 21291561 | SIGNOR-279669 | |
| SGK2 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 11154281 | SIGNOR-249132 |
| PRKAA1 | FOXO3 | Ser588 | QTLSDSLsGSSLYST | phosphorylation up-regulates activity | 17711846 | SIGNOR-249684 |
| PRKAA1 | FOXO3 | Thr179 | SSPDKRLtLSQIYEW | phosphorylation up-regulates activity | 17711846 | SIGNOR-238804 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 15084260 | SIGNOR-124207 |
| PPP2CA | dephosphorylation down-regulates ⊣ | FOXO3 PSer253 | dephosphorylation down-regulates ⊣ | FOXO3 | 20110348 | SIGNOR-163680 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249641 |
| MAPK3 | phosphorylation up-regulates → | FOXO3 PSer344 | phosphorylation down-regulates ⊣ | FOXO3 | 19282669 | SIGNOR-184573 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-236671 |
| AMPK | phosphorylation up-regulates → | FOXO3 PSer588 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-274096 |
| SGK1 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 11154281 | SIGNOR-249133 |
| AMPK | phosphorylation up-regulates → | FOXO3 PSer399 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-274095 |
| AKT | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249647 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249643 |
| DYRK1A | phosphorylation up-regulates → | FOXO3 PSer330 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-106833 |
| AKT | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183620 |
| MAPK14 | phosphorylation up-regulates → | FOXO3 PSer7 | phosphorylation up-regulates → | FOXO3 | 22128155 | SIGNOR-177927 |
| CSNK1A1 | phosphorylation up-regulates → | FOXO3 PSer321 | phosphorylation down-regulates ⊣ | FOXO3 | 20110348 | SIGNOR-163676 |
| MAPK1 | phosphorylation up-regulates → | FOXO3 PSer344 | phosphorylation down-regulates ⊣ | FOXO3 | 18204439 | SIGNOR-160411 |
| AMPK | phosphorylation up-regulates → | FOXO3 PSer399 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-249668 |
| AMPK | phosphorylation up-regulates → | FOXO3 PSer413 | phosphorylation up-regulates → | FOXO3 | 22848740 | SIGNOR-255756 |
| AMPK | phosphorylation up-regulates → | FOXO3 PSer588 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-249685 |
| PRKAA1 | phosphorylation up-regulates → | FOXO3 PSer555 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-249681 |
| PRKAA1 | phosphorylation up-regulates → | FOXO3 PSer413 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-249677 |
| AKT1 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249627 |
| CHUK | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 15084260 | SIGNOR-124203 |
| AKT | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249645 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-235960 |
| STK4 | phosphorylation up-regulates → | FOXO3 PSer209 | phosphorylation up-regulates → | FOXO3 | 18394876 | SIGNOR-178190 |
| SGK3 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 11154281 | SIGNOR-249135 |
| PRKAA1 | phosphorylation up-regulates → | FOXO3 PSer626 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-249687 |
| AKT1 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-252524 |
| IKBKE | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 23691078 | SIGNOR-202054 |
| MAPK8 | phosphorylation up-regulates → | FOXO3 PSer574 | phosphorylation up-regulates → | FOXO3 | 27669435 | SIGNOR-280030 |
| IKBKB | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183684 |
| AMPK | phosphorylation up-regulates → | FOXO3 PSer626 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-249688 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183648 |
| DYRK1A | phosphorylation up-regulates → | FOXO3 PSer330 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183674 |
| SGK1 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 11154281 | SIGNOR-236607 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249644 |
| AMPK | phosphorylation up-regulates → | FOXO3 PThr179 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-274094 |
| AKT1 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249626 |
| AMPK | phosphorylation up-regulates → | FOXO3 PSer555 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-249682 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249642 |
| PIM1 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 18593906 | SIGNOR-179304 |
| IKK-complex | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 15084260 | SIGNOR-216407 |
| PPP2CA | dephosphorylation down-regulates ⊣ | FOXO3 PThr32 | dephosphorylation down-regulates ⊣ | FOXO3 | 20110348 | SIGNOR-163684 |
| MAPK1 | phosphorylation up-regulates → | FOXO3 PSer294 | phosphorylation down-regulates ⊣ | FOXO3 | 18204439 | SIGNOR-160407 |
| AKT1 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-252522 |
| AMPK | phosphorylation up-regulates → | FOXO3 PSer555 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-274093 |
| AKT1 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-252523 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-236675 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249640 |
| CSNK1A1 | phosphorylation up-regulates → | FOXO3 PSer318 | phosphorylation down-regulates ⊣ | FOXO3 | 20110348 | SIGNOR-163672 |
| AKT | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249646 |
| PRKAA1 | phosphorylation up-regulates → | FOXO3 PSer399 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-249667 |
| PIM | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 18593906 | SIGNOR-259428 |
| AMPK | phosphorylation up-regulates → | FOXO3 PSer413 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-274098 |
| AKT1 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249625 |
| MAPKAPK5 | phosphorylation up-regulates → | FOXO3 PSer215 | phosphorylation up-regulates → | FOXO3 | 21329882 | SIGNOR-279469 |
| MAPK3 | phosphorylation up-regulates → | FOXO3 PSer425 | phosphorylation down-regulates ⊣ | FOXO3 | 19282669 | SIGNOR-184577 |
| MAPK3 | phosphorylation up-regulates → | FOXO3 PSer294 | phosphorylation down-regulates ⊣ | FOXO3 | 19282669 | SIGNOR-184569 |
| AMPK | phosphorylation up-regulates → | FOXO3 PSer413 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-249678 |
| IKK-complex | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-209769 |
| PIM1 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 18593906 | SIGNOR-179308 |
| STK4 | phosphorylation up-regulates → | FOXO3 PSer209 | phosphorylation up-regulates → | FOXO3 | 22898666 | SIGNOR-191851 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183652 |
| AKT | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183616 |
| PPP2CA | dephosphorylation down-regulates ⊣ | FOXO3 PThr32 | dephosphorylation down-regulates ⊣ | FOXO3 | 20110348 | SIGNOR-163688 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249639 |
| PIM | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 18593906 | SIGNOR-259429 |
| SGK2 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 11154281 | SIGNOR-249130 |
| AKT | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183612 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183644 |
| SGK1 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 11154281 | SIGNOR-249134 |
| AMPK | phosphorylation up-regulates → | FOXO3 PThr179 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-238813 |
| AMPK | phosphorylation up-regulates → | FOXO3 PSer626 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-274097 |
| MAPK1 | phosphorylation up-regulates → | FOXO3 PSer425 | phosphorylation down-regulates ⊣ | FOXO3 | 18204439 | SIGNOR-160415 |
| CDK6 | phosphorylation up-regulates → | FOXO3 PSer325 | phosphorylation up-regulates → | FOXO3 | 28778953 | SIGNOR-279023 |
| SGK2 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 11154281 | SIGNOR-249132 |
| PRKAA1 | phosphorylation up-regulates → | FOXO3 PSer588 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-249684 |
| PRKAA1 | phosphorylation up-regulates → | FOXO3 PThr179 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-238804 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKBKB | phosphorylation down-regulates | FOXO3 | SIGNOR-124207 |
| PPP2CA | dephosphorylation → up-regulates | FOXO3 | SIGNOR-163680 |
| AKT2 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249641 |
| MAPK3 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-184573 |
| AKT2 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-236671 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-274096 |
| SGK1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-249133 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-274095 |
| AKT | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249647 |
| AKT3 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249643 |
| DYRK1A | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-106833 |
| AKT | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-183620 |
| MAPK14 | phosphorylation → up-regulates | FOXO3 | SIGNOR-177927 |
| CSNK1A1 | phosphorylation down-regulates | FOXO3 | SIGNOR-163676 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-160411 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-249668 |
| AKT1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-175288 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-255756 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-249685 |
| PRKAA1 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-249681 |
| PRKAA1 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-249677 |
| CSNK1A1 | phosphorylation down-regulates | FOXO3 | SIGNOR-183661 |
| AKT1 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249627 |
| PRKAA1 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-219247 |
| CHUK | phosphorylation down-regulates | FOXO3 | SIGNOR-124203 |
| AKT | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249645 |
| AKT2 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-235960 |
| STK4 | phosphorylation → up-regulates | FOXO3 | SIGNOR-178190 |
| SGK3 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-249135 |
| PRKAA1 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-249687 |
| AKT1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-252524 |
| IKBKE | phosphorylation down-regulates | FOXO3 | SIGNOR-202054 |
| MAPK8 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-280030 |
| IKBKB | phosphorylation down-regulates | FOXO3 | SIGNOR-183684 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-249688 |
| AKT3 | phosphorylation down-regulates | FOXO3 | SIGNOR-183648 |
| DYRK1A | phosphorylation down-regulates | FOXO3 | SIGNOR-183674 |
| SGK1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-236607 |
| AKT3 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249644 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-274094 |
| AKT1 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249626 |
| Gbeta | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-270070 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-249682 |
| AKT3 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249642 |
| PIM1 | phosphorylation down-regulates | FOXO3 | SIGNOR-179304 |
| IKK-complex | phosphorylation down-regulates | FOXO3 | SIGNOR-216407 |
| MELK | phosphorylation → down-regulates quantity | FOXO3 | SIGNOR-279375 |
| PPP2CA | dephosphorylation → up-regulates | FOXO3 | SIGNOR-163684 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-160407 |
| AKT1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-252522 |
| ERK1/2 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-270175 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-274093 |
| PLK1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-279095 |
| AKT1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-252523 |
| AKT2 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-236675 |
| AKT2 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249640 |
| CSNK1A1 | phosphorylation down-regulates | FOXO3 | SIGNOR-163672 |
| AKT | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249646 |
| PRKAA1 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-255755 |
| PRKAA1 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-249667 |
| PIM | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-259428 |
| AKT | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-261526 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-274098 |
| AKT1 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249625 |
| MAPKAPK5 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-279469 |
| MAPK3 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-184577 |
| MAPK3 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-184569 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-249678 |
| IKK-complex | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-209769 |
| PIM1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-179308 |
| STK4 | phosphorylation → up-regulates | FOXO3 | SIGNOR-191851 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-216481 |
| AKT3 | phosphorylation down-regulates | FOXO3 | SIGNOR-183652 |
| AKT | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-183616 |
| PPP2CA | dephosphorylation → up-regulates activity | FOXO3 | SIGNOR-163688 |
| AKT2 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249639 |
| GNA13 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-278050 |
| PIM | phosphorylation down-regulates | FOXO3 | SIGNOR-259429 |
| SGK2 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-249130 |
| AKT | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-183612 |
| AKT3 | phosphorylation down-regulates | FOXO3 | SIGNOR-183644 |
| SGK1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-249134 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-238813 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-274097 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-160415 |
| CDK6 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-279023 |
| TYRO3 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-279669 |
| SGK2 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-249132 |
| PRKAA1 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-249684 |
| PRKAA1 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-238804 |
