Summary

Name FOXO3
Full Name Forkhead box protein O3
Synonyms AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1 | FKHRL1, FOXO3A
Primary ID O43524
Links - -
Type protein
Relations 131
Pathways AMPK Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Myofiber: Glucocorticoid-induced atrophy, Myofiber: IL6 and atrophy, Satellite: miRNA network, Thyroid cancer
Function Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882). Acts as a positive regulator of autophagy in skeletal muscle

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation FOXO3 0.672
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.511
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.396
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.2
Publications: 4 Organism: Homo Sapiens, Mus Musculus
Pathways:FLT3 in AML, AMPK Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Thyroid cancer
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.696
Publications: 3
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.696
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.2
Publications: 3
Pathways:FLT3 in AML, AMPK Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Thyroid cancer
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.45
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.908
Publications: 3
Pathways:IGF and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.742
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation FOXO3 0.412
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.742
Publications: 3
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.908
Publications: 4 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.787
Publications: 3 Organism: Homo Sapiens
Pathways:Insulin Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.583
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.711
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.369
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.369
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FOXO3 0.509
Publications: 8 Organism: Homo Sapiens, , Caenorhabditis Elegans
+ up-regulates activity img/direct-activation.png phosphorylation FOXO3 0.395
Publications: 14 Organism: Homo Sapiens, In Vitro, Mus Musculus
Pathways:AMPK Signaling
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.532
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.674
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.532
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.422
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.548
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOXO3 0.514
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation FOXO3 0.412
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.396
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FOXO3 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png transcriptional regulation CDKN1B 0.737
Publications: 1 Organism: Mus Musculus
Pathways:Integrin Signaling
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation STK11 0.625
Publications: 1
Pathways:AMPK Signaling
+ up-regulates activity img/direct-activation.png deacetylation FOXO3 0.38
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IDH1 0.252
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png deacetylation FOXO3 0.909
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:AMPK Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML, AMPK Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Thyroid cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FASLG 0.697
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOXO3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BCL2L11 0.763
Publications: 1 Organism: Mus Musculus
Pathways:Inhibition of Apoptosis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FBXO32 0.457
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Tissue: Muscle
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TSC22D3 0.41
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.737
Publications: 1 Organism: Mus Musculus
Pathways:Integrin Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOXO3 0.313
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deacetylation FOXO3 0.909
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ down-regulates img/direct_inhibition.png binding FOXO3 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell_cycle_block 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ up-regulates img/indirect-activation.png Cell_death 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png FOXO3 0.407
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ up-regulates activity img/indirect-activation.png Autophagy 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ up-regulates quantity img/direct-activation.png transcriptional regulation FOXO3 0.2
Publications: 1
Pathways:FLT3 in AML, AMPK Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, IGF and Myogenesis, Thyroid cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.401
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH 0.388
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/indirect_inhibition.png FOXO3 0.317
Publications: 1 Organism: Mus Musculus
Pathways:FLT3 in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2L11 0.763
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH3 0.314
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DIO 0.353
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GALT 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Ovary
+ down-regulates img/indirect_inhibition.png Cell_cycle_progress 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TRIM63 0.43
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis
+ up-regulates activity img/direct-activation.png transcriptional regulation TSC22D3 0.41
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png transcriptional regulation FOXO3 0.431
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png hydroxylation FOXO3 0.294
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization FOXO3 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Muscle_atrophy 0.7
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation FOXO3 0.2
Publications: 1 Organism: Bos Taurus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FOXO3 0.407
Publications: 1 Organism: Mus Musculus
Pathways:AMPK Signaling
+ up-regulates quantity img/direct-activation.png transcriptional regulation TSC1 0.465
Publications: 1 Organism: Mus Musculus
Pathways:Insulin Signaling
+ up-regulates quantity img/direct-activation.png transcriptional regulation MIR1-1 0.4
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH1 0.388
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML, Inhibition of Apoptosis, Integrin Signaling, Thyroid cancer
+ up-regulates quantity img/direct-activation.png transcriptional regulation RBL2 0.298
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CITED2 0.452
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DIO2 0.353
Publications: 1