Summary

Name FOXO3
Full Name Forkhead box protein O3
Synonyms AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1 | FKHRL1, FOXO3A
Primary ID O43524
Links - -
Type protein
Relations 112
Pathways AMPK Signaling, Insulin Receptor, IGF and Myogenesis, Inhibition of Apoptosis, Thyroid cancer, Integrin Signalling, FLT3 in AML
Function Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation FOXO3 0.42
Publications: 2 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.35
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.2
Publications: 3
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.22
Publications: 3 Organism: Homo Sapiens
Pathways:Insulin Receptor
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.42
Publications: 3 Organism: Homo Sapiens
Pathways:FLT3 in AML, AMPK Signaling, Insulin Receptor, Inhibition of Apoptosis, Integrin Signalling, Thyroid cancer
+ up-regulates img/direct-activation.png dephosphorylation FOXO3 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.14
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3 in AML
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.28
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.6
Publications: 4 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.2
Publications: 3
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.42
Publications: 3
Pathways:FLT3 in AML, AMPK Signaling, Insulin Receptor, Inhibition of Apoptosis, Integrin Signalling, Thyroid cancer
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.4
Publications: 3
Pathways:IGF and Myogenesis
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FOXO3 0.44
Publications: 8 Organism: Homo Sapiens, , Caenorhabditis Elegans
Tissue: Liver
+ up-regulates activity img/direct-activation.png phosphorylation FOXO3 0.31
Publications: 8 Organism: Homo Sapiens, Mus Musculus
Pathways:AMPK Signaling
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.37
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ up-regulates img/direct-activation.png phosphorylation FOXO3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FOXO3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell Cycle Block 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ up-regulates quantity img/indirect-activation.png transcriptional activation DIO2 0.14
Publications: 1
+ up-regulates quantity img/direct-activation.png transcriptional activation TSC1 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding FOXO3 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deacetylation FOXO3 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Muscle
+ up-regulates img/indirect-activation.png Apoptosis 0.55
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML, Inhibition of Apoptosis, Integrin Signalling, Thyroid cancer
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FOXO3 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Ovary
+ up-regulates quantity img/direct-activation.png transcriptional regulation FOXO3 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Liver
+ up-regulates quantity img/direct-activation.png transcriptional regulation FOXO3 0.14
Publications: 1
Tissue: Liver
Pathways:FLT3 in AML, AMPK Signaling, Insulin Receptor, Inhibition of Apoptosis, Integrin Signalling, IGF and Myogenesis, Thyroid cancer
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation STK11 0.14
Publications: 1
Pathways:AMPK Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CITED2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FBXO32 0.2
Publications: 3 Organism: Mus Musculus, Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis
+ down-regulates activity img/indirect_inhibition.png deacetylation FOXO3 0.53
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:AMPK Signaling
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TSC22D3 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2L11 0.3
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ up-regulates quantity img/direct-activation.png transcriptional regulation RBL2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png transcriptional activation TSC22D3 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOXO3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png deacetylation FOXO3 0.47
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ up-regulates quantity img/direct-activation.png transcriptional regulation CDKN1B 0.22
Publications: 1 Organism: Mus Musculus
Pathways:Integrin Signalling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOXO3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization FOXO3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png FOXO3 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
Pathways:AMPK Signaling
+ down-regulates activity img/direct_inhibition.png deacetylation FOXO3 0.53
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FOXO3 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:AMPK Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FASLG 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TRIM63 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis
+ up-regulates quantity img/direct-activation.png transcriptional regulation MIR1-1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Muscle atrophy 0.22
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GALT 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Ovary
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates img/indirect-activation.png Cell death 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH3 0.14
Publications: 1 Organism: Mus Musculus