| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 19188143 | SIGNOR-183620 |
| AKT | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249645 |
| AKT1 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 19188143 | SIGNOR-252524 |
| AKT3 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249642 |
| PPP2CA | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | dephosphorylation up-regulates | 20110348 | SIGNOR-163684 |
| AKT2 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 19188143 | SIGNOR-236675 |
| PIM | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 18593906 | SIGNOR-259428 |
| AKT1 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249625 |
| PIM1 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 18593906 | SIGNOR-179308 |
| AKT3 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates | 19188143 | SIGNOR-183652 |
| PPP2CA | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | dephosphorylation up-regulates activity | 20110348 | SIGNOR-163688 |
| AKT2 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249639 |
| SGK1 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 11154281 | SIGNOR-249134 |
| SGK2 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 11154281 | SIGNOR-249132 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183620 |
| AKT | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249645 |
| AKT1 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-252524 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249642 |
| PPP2CA | dephosphorylation down-regulates ⊣ | FOXO3 PThr32 | dephosphorylation down-regulates ⊣ | FOXO3 | 20110348 | SIGNOR-163684 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-236675 |
| PIM | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 18593906 | SIGNOR-259428 |
| AKT1 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249625 |
| PIM1 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 18593906 | SIGNOR-179308 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183652 |
| PPP2CA | dephosphorylation down-regulates ⊣ | FOXO3 PThr32 | dephosphorylation down-regulates ⊣ | FOXO3 | 20110348 | SIGNOR-163688 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249639 |
| SGK1 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 11154281 | SIGNOR-249134 |
| SGK2 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 11154281 | SIGNOR-249132 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-183620 |
| AKT | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249645 |
| AKT1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-252524 |
| AKT3 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249642 |
| PPP2CA | dephosphorylation → up-regulates | FOXO3 | SIGNOR-163684 |
| AKT2 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-236675 |
| PIM | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-259428 |
| AKT1 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249625 |
| PIM1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-179308 |
| AKT3 | phosphorylation down-regulates | FOXO3 | SIGNOR-183652 |
| PPP2CA | dephosphorylation → up-regulates activity | FOXO3 | SIGNOR-163688 |
| AKT2 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249639 |
| SGK1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-249134 |
| SGK2 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-249132 |
