| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | FOXO3 | Thr179 | SSPDKRLtLSQIYEW | phosphorylation up-regulates activity | 17711846 | SIGNOR-238813 |
| PRKAA1 | FOXO3 | Thr179 | SSPDKRLtLSQIYEW | phosphorylation up-regulates activity | 17711846 | SIGNOR-238804 |
| AMPK | FOXO3 | Thr179 | SSPDKRLtLSQIYEW | phosphorylation up-regulates activity | 17711846 | SIGNOR-274094 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | phosphorylation up-regulates → | FOXO3 PThr179 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-238813 |
| PRKAA1 | phosphorylation up-regulates → | FOXO3 PThr179 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-238804 |
| AMPK | phosphorylation up-regulates → | FOXO3 PThr179 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-274094 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-238813 |
| PRKAA1 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-238804 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-274094 |