| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKK-complex | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates quantity by destabilization | 19188143 | SIGNOR-209769 |
| IKBKB | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 15084260 | SIGNOR-124207 |
| CHUK | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 15084260 | SIGNOR-124203 |
| IKBKE | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 23691078 | SIGNOR-202054 |
| IKBKB | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 19188143 | SIGNOR-183684 |
| IKK-complex | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 15084260 | SIGNOR-216407 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKK-complex | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-209769 |
| IKBKB | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 15084260 | SIGNOR-124207 |
| CHUK | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 15084260 | SIGNOR-124203 |
| IKBKE | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 23691078 | SIGNOR-202054 |
| IKBKB | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183684 |
| IKK-complex | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 15084260 | SIGNOR-216407 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKK-complex | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-209769 |
| IKBKB | phosphorylation down-regulates | FOXO3 | SIGNOR-124207 |
| CHUK | phosphorylation down-regulates | FOXO3 | SIGNOR-124203 |
| IKBKE | phosphorylation down-regulates | FOXO3 | SIGNOR-202054 |
| IKBKB | phosphorylation down-regulates | FOXO3 | SIGNOR-183684 |
| IKK-complex | phosphorylation down-regulates | FOXO3 | SIGNOR-216407 |
