| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | FOXO3 | Ser294 | QLSKWPGsPTSRSSD | phosphorylation down-regulates quantity by destabilization | 19282669 | SIGNOR-184569 |
| MAPK1 | FOXO3 | Ser294 | QLSKWPGsPTSRSSD | phosphorylation down-regulates quantity by destabilization | 18204439 | SIGNOR-160407 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | FOXO3 PSer294 | phosphorylation down-regulates ⊣ | FOXO3 | 19282669 | SIGNOR-184569 |
| MAPK1 | phosphorylation up-regulates → | FOXO3 PSer294 | phosphorylation down-regulates ⊣ | FOXO3 | 18204439 | SIGNOR-160407 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation![]() down-regulates quantity by destabilization | FOXO3 | SIGNOR-184569 |
| MAPK1 | phosphorylation![]() down-regulates quantity by destabilization | FOXO3 | SIGNOR-160407 |