| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 19188143 | SIGNOR-236671 |
| AKT2 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249640 |
| AKT | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249646 |
| PPP2CA | FOXO3 | Ser253 | APRRRAVsMDNSNKY | dephosphorylation up-regulates | 20110348 | SIGNOR-163680 |
| AKT3 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249643 |
| AKT3 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates | 19188143 | SIGNOR-183644 |
| AKT1 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 19188143 | SIGNOR-252522 |
| PIM1 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates | 18593906 | SIGNOR-179304 |
| SGK3 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 11154281 | SIGNOR-249135 |
| SGK2 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 11154281 | SIGNOR-249130 |
| PIM | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates | 18593906 | SIGNOR-259429 |
| AKT1 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249626 |
| AKT | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 19188143 | SIGNOR-183612 |
| SGK1 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 11154281 | SIGNOR-249133 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-236671 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249640 |
| AKT | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249646 |
| PPP2CA | dephosphorylation down-regulates ⊣ | FOXO3 PSer253 | dephosphorylation down-regulates ⊣ | FOXO3 | 20110348 | SIGNOR-163680 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249643 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183644 |
| AKT1 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-252522 |
| PIM1 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 18593906 | SIGNOR-179304 |
| SGK3 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 11154281 | SIGNOR-249135 |
| SGK2 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 11154281 | SIGNOR-249130 |
| PIM | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 18593906 | SIGNOR-259429 |
| AKT1 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249626 |
| AKT | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183612 |
| SGK1 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 11154281 | SIGNOR-249133 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT2 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-236671 |
| AKT2 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249640 |
| AKT | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249646 |
| PPP2CA | dephosphorylation → up-regulates | FOXO3 | SIGNOR-163680 |
| AKT3 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249643 |
| AKT3 | phosphorylation down-regulates | FOXO3 | SIGNOR-183644 |
| AKT1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-252522 |
| PIM1 | phosphorylation down-regulates | FOXO3 | SIGNOR-179304 |
| SGK3 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-249135 |
| SGK2 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-249130 |
| PIM | phosphorylation down-regulates | FOXO3 | SIGNOR-259429 |
| AKT1 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249626 |
| AKT | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-183612 |
| SGK1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-249133 |
