| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | FOXO3 | Ser588 | QTLSDSLsGSSLYST | phosphorylation up-regulates activity | 17711846 | SIGNOR-249685 |
| PRKAA1 | FOXO3 | Ser588 | QTLSDSLsGSSLYST | phosphorylation up-regulates activity | 17711846 | SIGNOR-249684 |
| AMPK | FOXO3 | Ser588 | QTLSDSLsGSSLYST | phosphorylation up-regulates activity | 17711846 | SIGNOR-274096 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | phosphorylation up-regulates → | FOXO3 PSer588 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-249685 |
| PRKAA1 | phosphorylation up-regulates → | FOXO3 PSer588 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-249684 |
| AMPK | phosphorylation up-regulates → | FOXO3 PSer588 | phosphorylation up-regulates → | FOXO3 | 17711846 | SIGNOR-274096 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-249685 |
| PRKAA1 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-249684 |
| AMPK | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-274096 |