| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 19188143 | SIGNOR-183616 |
| AKT2 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249641 |
| AKT | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249647 |
| AKT1 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249627 |
| AKT2 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 19188143 | SIGNOR-235960 |
| AKT3 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates | 19188143 | SIGNOR-183648 |
| SGK1 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 11154281 | SIGNOR-236607 |
| AKT3 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249644 |
| AKT1 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 19188143 | SIGNOR-252523 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183616 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249641 |
| AKT | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249647 |
| AKT1 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249627 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-235960 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183648 |
| SGK1 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 11154281 | SIGNOR-236607 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249644 |
| AKT1 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-252523 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-183616 |
| AKT2 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249641 |
| AKT | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249647 |
| AKT1 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249627 |
| AKT2 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-235960 |
| AKT3 | phosphorylation down-regulates | FOXO3 | SIGNOR-183648 |
| SGK1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-236607 |
| AKT3 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249644 |
| AKT1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-252523 |
