| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ZAP70 | LAT | Tyr 132 | DYHNPGyLVVLPD | phosphorylation up-regulates activity | 29915297 | SIGNOR-274561 |
| ZAP70 | LAT | Tyr156 | ADEDEDDyHNPGYLV | phosphorylation up-regulates activity | 11368773 | SIGNOR-247018 |
| PTPN1 | LAT | – | dephosphorylation down-regulates activity | 12857726 | SIGNOR-248403 | |
| ZAP70 | LAT | Tyr200 | SMESIDDyVNVPESG | phosphorylation up-regulates activity | 11368773 | SIGNOR-247026 |
| PTPRJ | LAT | – | dephosphorylation down-regulates | 11259588 | SIGNOR-105787 | |
| FYN | LAT | Tyr200 | SMESIDDyVNVPESG | phosphorylation up-regulates | 16938345 | SIGNOR-149174 |
| ZAP70 | LAT | Tyr255 | EEEGAPDyENLQELN | phosphorylation up-regulates activity | 11368773 | SIGNOR-247034 |
| FYN | LAT | Tyr220 | SLDGSREyVNVSQEL | phosphorylation up-regulates | 16938345 | SIGNOR-148931 |
| ZAP70 | LAT | Tyr220 | SLDGSREyVNVSQEL | phosphorylation up-regulates activity | 11368773 | SIGNOR-247030 |
| ZAP70 | LAT | Tyr161 | DDYHNPGyLVVLPDS | phosphorylation up-regulates activity | 11368773 | SIGNOR-247022 |
| ZAP70 | LAT | Tyr191 | LDGSREyVNVSQE | phosphorylation up-regulates activity | 29915297 | SIGNOR-274562 |
| STK25 | LAT | – | phosphorylation up-regulates activity | 30948712 | SIGNOR-279294 | |
| MAPK8 | LAT | Thr184 | PSAPALStPGIRDSA | phosphorylation down-regulates | 15192708 | SIGNOR-125774 |
| PTPN1 | LAT | – | dephosphorylation down-regulates | 12857726 | SIGNOR-103599 | |
| LCK | LAT | Tyr200 | SMESIDDyVNVPESG | phosphorylation up-regulates | 16938345 | SIGNOR-149182 |
| PTPRJ | LAT | – | dephosphorylation down-regulates activity | 11259588 | SIGNOR-248696 | |
| NUAK2 | LAT | – | phosphorylation down-regulates activity | 30158528 | SIGNOR-280052 | |
| LCK | LAT | Tyr220 | SLDGSREyVNVSQEL | phosphorylation up-regulates | 16938345 | SIGNOR-149186 |
| STK4 | LAT | – | phosphorylation up-regulates activity | 26456820 | SIGNOR-279661 | |
| MAPK3 | LAT | Thr184 | PSAPALStPGIRDSA | phosphorylation down-regulates | 15192708 | SIGNOR-125770 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ZAP70 | phosphorylation up-regulates → | LAT PTyr 132 | phosphorylation up-regulates → | LAT | 29915297 | SIGNOR-274561 |
| ZAP70 | phosphorylation up-regulates → | LAT PTyr156 | phosphorylation up-regulates → | LAT | 11368773 | SIGNOR-247018 |
| ZAP70 | phosphorylation up-regulates → | LAT PTyr200 | phosphorylation up-regulates → | LAT | 11368773 | SIGNOR-247026 |
| FYN | phosphorylation up-regulates → | LAT PTyr200 | phosphorylation up-regulates → | LAT | 16938345 | SIGNOR-149174 |
| ZAP70 | phosphorylation up-regulates → | LAT PTyr255 | phosphorylation up-regulates → | LAT | 11368773 | SIGNOR-247034 |
| FYN | phosphorylation up-regulates → | LAT PTyr220 | phosphorylation up-regulates → | LAT | 16938345 | SIGNOR-148931 |
| ZAP70 | phosphorylation up-regulates → | LAT PTyr220 | phosphorylation up-regulates → | LAT | 11368773 | SIGNOR-247030 |
| ZAP70 | phosphorylation up-regulates → | LAT PTyr161 | phosphorylation up-regulates → | LAT | 11368773 | SIGNOR-247022 |
| ZAP70 | phosphorylation up-regulates → | LAT PTyr191 | phosphorylation up-regulates → | LAT | 29915297 | SIGNOR-274562 |
| MAPK8 | phosphorylation up-regulates → | LAT PThr184 | phosphorylation down-regulates ⊣ | LAT | 15192708 | SIGNOR-125774 |
| LCK | phosphorylation up-regulates → | LAT PTyr200 | phosphorylation up-regulates → | LAT | 16938345 | SIGNOR-149182 |
| LCK | phosphorylation up-regulates → | LAT PTyr220 | phosphorylation up-regulates → | LAT | 16938345 | SIGNOR-149186 |
| MAPK3 | phosphorylation up-regulates → | LAT PThr184 | phosphorylation down-regulates ⊣ | LAT | 15192708 | SIGNOR-125770 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ZAP70 | phosphorylation → up-regulates activity | LAT | SIGNOR-274561 |
| ZAP70 | phosphorylation → up-regulates activity | LAT | SIGNOR-247018 |
| PTPN1 | dephosphorylation → down-regulates activity | LAT | SIGNOR-248403 |
| ZAP70 | phosphorylation → up-regulates activity | LAT | SIGNOR-247026 |
| PTPRJ | dephosphorylation down-regulates | LAT | SIGNOR-105787 |
| FYN | phosphorylation → up-regulates | LAT | SIGNOR-149174 |
| ZAP70 | phosphorylation → up-regulates activity | LAT | SIGNOR-247034 |
| FYN | phosphorylation → up-regulates | LAT | SIGNOR-148931 |
| ZAP70 | phosphorylation → up-regulates activity | LAT | SIGNOR-247030 |
| ZAP70 | phosphorylation → up-regulates activity | LAT | SIGNOR-247022 |
| ZAP70 | phosphorylation → up-regulates activity | LAT | SIGNOR-274562 |
| STK25 | phosphorylation → up-regulates activity | LAT | SIGNOR-279294 |
| MAPK8 | phosphorylation down-regulates | LAT | SIGNOR-125774 |
| PTPN1 | dephosphorylation down-regulates | LAT | SIGNOR-103599 |
| LCK | phosphorylation → up-regulates | LAT | SIGNOR-149182 |
| PTPRJ | dephosphorylation → down-regulates activity | LAT | SIGNOR-248696 |
| NUAK2 | phosphorylation → down-regulates activity | LAT | SIGNOR-280052 |
| LCK | phosphorylation → up-regulates | LAT | SIGNOR-149186 |
| STK4 | phosphorylation → up-regulates activity | LAT | SIGNOR-279661 |
| MAPK3 | phosphorylation down-regulates | LAT | SIGNOR-125770 |
