Summary

Name LAT
Full Name Linker for activation of T-cells family member 1
Synonyms 36 kDa phospho-tyrosine adapter protein, pp36, p36-38
Primary ID O43561
Links - -
Type protein
Relations 23
Pathways T cell activation
Function Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation LAT 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LAT 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LAT 0.69
Publications: 5 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png phosphorylation LAT 0.22
Publications: 2 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png phosphorylation LAT 0.54
Publications: 2 Organism: Homo Sapiens
Pathways:T cell activation
+ down-regulates img/direct_inhibition.png dephosphorylation LAT 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PI3K 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3CA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.38
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ down-regulates img/direct_inhibition.png dephosphorylation LAT 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding VAV1 0.46
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation LAT 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation LAT 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3R2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PLCG1 0.71
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png binding GRB2 0.67
Publications: 2 Organism: Homo Sapiens
Pathways:T cell activation