| Name | DCX |
| ID | O43602 |
| Role | substrate |
| Enzymatic Domains |
Doublecortin 1 53-139 PROSITE-ProRule
Doublecortin 2 180-263 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5/CDK5R1 | DCX | Ser28 | SRMNGLPsPTHSAHC | phosphorylation unknown | 14741103 | SIGNOR-250654 |
| MAPK8 | DCX | – | phosphorylation up-regulates activity | 28701917 | SIGNOR-279228 | |
| CDK5/CDK5R1 | DCX | Thr336 | SKQSPIStPTSPGSL | phosphorylation unknown | 14741103 | SIGNOR-250660 |
| CDK5/CDK5R1 | DCX | Ser287 | ATAGPKAsPTPQKTS | phosphorylation unknown | 14741103 | SIGNOR-250655 |
| CDK5/CDK5R1 | DCX | Thr289 | AGPKASPtPQKTSAK | phosphorylation unknown | 14741103 | SIGNOR-250656 |
| CDK5/CDK5R1 | DCX | Ser332 | STPKSKQsPISTPTS | phosphorylation unknown | 14741103 | SIGNOR-250667 |
| CDK5/CDK5R1 | DCX | Ser297 | PQKTSAKsPGPMRRS | phosphorylation up-regulates activity | 14741103 | SIGNOR-250657 |
| CDK5/CDK5R1 | DCX | Thr326 | TSSSQLStPKSKQSP | phosphorylation unknown | 14741103 | SIGNOR-250659 |
| CDK5/CDK5R1 | DCX | Ser339 | SPISTPTsPGSLRKH | phosphorylation unknown | 14741103 | SIGNOR-250673 |
| MAPK8 | DCX | – | phosphorylation up-regulates activity | 21477071 | SIGNOR-279217 | |
| GSK3B | DCX | Ser332 | STPKSKQsPISTPTS | phosphorylation up-regulates activity | 21159948 | SIGNOR-170755 |
| CDK5/CDK5R1 | DCX | Ser306 | GPMRRSKsPADSGND | phosphorylation unknown | 14741103 | SIGNOR-250658 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PSer28 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250654 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PThr336 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250660 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PSer287 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250655 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PThr289 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250656 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PSer332 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250667 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PSer297 | phosphorylation up-regulates → | DCX | 14741103 | SIGNOR-250657 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PThr326 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250659 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PSer339 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250673 |
| GSK3B | phosphorylation up-regulates → | DCX PSer332 | phosphorylation up-regulates → | DCX | 21159948 | SIGNOR-170755 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PSer306 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250658 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250654 |
| MAPK8 | phosphorylation → up-regulates activity | DCX | SIGNOR-279228 |
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250660 |
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250655 |
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250656 |
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250667 |
| CDK5/CDK5R1 | phosphorylation → up-regulates activity | DCX | SIGNOR-250657 |
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250659 |
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250673 |
| MAPK8 | phosphorylation → up-regulates activity | DCX | SIGNOR-279217 |
| GSK3B | phosphorylation → up-regulates activity | DCX | SIGNOR-170755 |
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250658 |