Summary

Name DCX
Full Name Neuronal migration protein doublecortin
Synonyms Doublin, Lissencephalin-X, Lis-X | DBCN, LISX
Primary ID O43602
Links - -
Type protein
Relations 11
Function Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation DCX 0.14
Publications: 8 Organism: In Vitro, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DCX 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DCX 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DCX 0.14
Publications: 1 Organism: Rattus Norvegicus