| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PINK1 | PRKN | Ser65 | NCDLDQQsIVHIVQR | phosphorylation up-regulates | 22724072 | SIGNOR-197976 |
| PINK1 | PRKN | Ser65 | NCDLDQQsIVHIVQR | phosphorylation up-regulates activity | 22724072 | SIGNOR-270345 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PINK1 | phosphorylation up-regulates → | PRKN PSer65 | phosphorylation up-regulates → | PRKN | 22724072 | SIGNOR-197976 |
| PINK1 | phosphorylation up-regulates → | PRKN PSer65 | phosphorylation up-regulates → | PRKN | 22724072 | SIGNOR-270345 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PINK1 | phosphorylation → up-regulates | PRKN | SIGNOR-197976 |
| PINK1 | phosphorylation → up-regulates activity | PRKN | SIGNOR-270345 |
