Summary

Name PRKN
Full Name E3 ubiquitin-protein ligase parkin
Synonyms Parkin, Parkinson juvenile disease protein 2, Parkinson disease protein 2 | PRKN
Primary ID O60260
Links - -
Type protein
Relations 9
Pathways Parkinson disease
Function Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2 (PubMed:10973942, PubMed:10888878, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:16135753, PubMed:21376232, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25621951). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation PRKN 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation PRKN 0.53
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson disease
+ down-regulates img/direct_inhibition.png phosphorylation PRKN 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination RANBP2 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination EPS15 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination SNCA 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson disease
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination GPR37 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PRKN 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson disease
+ up-regulates img/direct-activation.png ubiquitination EPS15 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain