| Name | KDM1A |
| ID | O60341 |
| Role | substrate |
| Enzymatic Domains |
SWIRM 174-273 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | KDM1A | Ser131 | DESLANLsEDEYYSE | phosphorylation up-regulates activity | 25999347 | SIGNOR-276902 |
| PPM1D | KDM1A | Ser131 | DESLANLsEDEYYSE | dephosphorylation down-regulates activity | 25999347 | SIGNOR-276904 |
| PRKCA | KDM1A | Ser111 | TPEGRRTsRRKRAKV | phosphorylation up-regulates activity | 29395062 | SIGNOR-279425 |
| CSNK2A1 | KDM1A | Ser137 | LSEDEYYsEEERNAK | phosphorylation up-regulates activity | 25999347 | SIGNOR-276903 |
| PPM1D | KDM1A | Ser137 | LSEDEYYsEEERNAK | dephosphorylation down-regulates activity | 25999347 | SIGNOR-276905 |
| GSK3B | KDM1A | Ser683 | NLFGHVGsTTASRGE | phosphorylation up-regulates activity | 27501329 | SIGNOR-278225 |
| PRKCQ | KDM1A | Ser111 | TPEGRRTsRRKRAKV | phosphorylation down-regulates activity | 29311580 | SIGNOR-279104 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | KDM1A PSer131 | phosphorylation up-regulates → | KDM1A | 25999347 | SIGNOR-276902 |
| PPM1D | dephosphorylation down-regulates ⊣ | KDM1A PSer131 | dephosphorylation up-regulates → | KDM1A | 25999347 | SIGNOR-276904 |
| PRKCA | phosphorylation up-regulates → | KDM1A PSer111 | phosphorylation up-regulates → | KDM1A | 29395062 | SIGNOR-279425 |
| CSNK2A1 | phosphorylation up-regulates → | KDM1A PSer137 | phosphorylation up-regulates → | KDM1A | 25999347 | SIGNOR-276903 |
| PPM1D | dephosphorylation down-regulates ⊣ | KDM1A PSer137 | dephosphorylation up-regulates → | KDM1A | 25999347 | SIGNOR-276905 |
| GSK3B | phosphorylation up-regulates → | KDM1A PSer683 | phosphorylation up-regulates → | KDM1A | 27501329 | SIGNOR-278225 |
| PRKCQ | phosphorylation up-regulates → | KDM1A PSer111 | phosphorylation down-regulates ⊣ | KDM1A | 29311580 | SIGNOR-279104 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation → up-regulates activity | KDM1A | SIGNOR-276902 |
| PPM1D | dephosphorylation → down-regulates activity | KDM1A | SIGNOR-276904 |
| PRKCA | phosphorylation → up-regulates activity | KDM1A | SIGNOR-279425 |
| CSNK2A1 | phosphorylation → up-regulates activity | KDM1A | SIGNOR-276903 |
| PPM1D | dephosphorylation → down-regulates activity | KDM1A | SIGNOR-276905 |
| GSK3B | phosphorylation → up-regulates activity | KDM1A | SIGNOR-278225 |
| PRKCQ | phosphorylation → down-regulates activity | KDM1A | SIGNOR-279104 |