3.0
Summary
| Name |  KDM1AView Modifications |
| Full Name | Lysine-specific histone demethylase 1A |
| Synonyms | BRAF35-HDAC complex protein BHC110, Flavin-containing amine oxidase domain-containing protein 2 | AOF2, KDM1, KIAA0601, LSD1 |
| Primary ID | O60341 |
| Links |  -  -  |
| Type | protein |
| Relations | 16 |
| Function | Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16140033, PubMed:16079794, PubMed:16079795, PubMed:16223729). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16140033, PubMed:16079794, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | KDM1A | up-regulates activity 
demethylation
|
H3-3A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM1A | up-regulates activity
demethylation
|
H3C1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM1A | up-regulates activity
demethylation
|
H3-4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GTF2I | up-regulates activity
relocalization, binding
|
KDM1A | 0.418 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | HIF1A | down-regulates quantity by repression 
transcriptional regulation
|
KDM1A | 0.27 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM1A | form complex 
binding
|
CoREST-HDAC complex | 0.74 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EPAS1 | down-regulates quantity by repression
transcriptional regulation
|
KDM1A | 0.284 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM4C | up-regulates activity
binding
|
KDM1A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM1A | down-regulates 
|
Epigenetic_regulation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BRMS1 | up-regulates activity
binding
|
KDM1A | 0.262 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RCOR1 | up-regulates activity
binding
|
KDM1A | 0.954 |
| Publications: | 1 | Organism: | In Vitro | |
| + | ASXL3 | down-regulates activity
binding
|
KDM1A | 0.272 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM1A | up-regulates activity
demethylation
|
Histone H3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM1A | form complex
binding
|
BHC complex | 0.794 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PHF21A | down-regulates activity
binding
|
KDM1A | 0.703 |
| Publications: | 1 | Organism: | In Vitro | |