| Name | TBC1D4 |
| ID | O60343 |
| Role | substrate |
| Enzymatic Domains |
PID 1 53-209 PROSITE-ProRule
PID 2 312-468 PROSITE-ProRule
Rab-GAP TBC 918-1112 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | TBC1D4 | Thr642 | QFRRRAHtFSHPPSS | phosphorylation unknown | 16880201 | SIGNOR-252494 |
| AKT | TBC1D4 | Ser588 | RMRGRLGsVDSFERS | phosphorylation unknown | 11994271 | SIGNOR-245268 |
| AKT1 | TBC1D4 | – | phosphorylation down-regulates | 12637568 | SIGNOR-252594 | |
| AKT2 | TBC1D4 | – | phosphorylation down-regulates activity | 33810522 | SIGNOR-280179 | |
| AKT | TBC1D4 | Thr642 | QFRRRAHtFSHPPSS | phosphorylation unknown | 16880201 | SIGNOR-148342 |
| AKT | TBC1D4 | – | phosphorylation down-regulates | 12637568 | SIGNOR-99300 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | TBC1D4 PThr642 | phosphorylation down-regulates ⊣ | TBC1D4 | 16880201 | SIGNOR-252494 |
| AKT | phosphorylation up-regulates → | TBC1D4 PSer588 | phosphorylation down-regulates ⊣ | TBC1D4 | 11994271 | SIGNOR-245268 |
| AKT | phosphorylation up-regulates → | TBC1D4 PThr642 | phosphorylation down-regulates ⊣ | TBC1D4 | 16880201 | SIGNOR-148342 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → unknown | TBC1D4 | SIGNOR-252494 |
| AKT | phosphorylation → unknown | TBC1D4 | SIGNOR-245268 |
| AKT1 | phosphorylation down-regulates | TBC1D4 | SIGNOR-252594 |
| AKT2 | phosphorylation → down-regulates activity | TBC1D4 | SIGNOR-280179 |
| AKT | phosphorylation → unknown | TBC1D4 | SIGNOR-148342 |
| AKT | phosphorylation down-regulates | TBC1D4 | SIGNOR-99300 |