Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
AKT2	TBC1D4	–		phosphorylation down-regulates activity	33810522	SIGNOR-280179
AKT	TBC1D4	–		phosphorylation down-regulates	12637568	SIGNOR-99300
AKT1	TBC1D4	–		phosphorylation down-regulates	12637568	SIGNOR-252594
AKT	TBC1D4	Ser588 View in OncoXplorer	RMRGRLGsVDSFERS	phosphorylation unknown	11994271	SIGNOR-245268
AKT1	TBC1D4	Thr642 View in OncoXplorer	QFRRRAHtFSHPPSS	phosphorylation unknown	16880201	SIGNOR-252494
AKT	TBC1D4	Thr642 View in OncoXplorer	QFRRRAHtFSHPPSS	phosphorylation unknown	16880201	SIGNOR-148342

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
AKT	phosphorylation up-regulates →	TBC1D4 PSer588	phosphorylation down-regulates ⊣	TBC1D4	11994271	SIGNOR-245268
AKT1	phosphorylation up-regulates →	TBC1D4 PThr642	phosphorylation down-regulates ⊣	TBC1D4	16880201	SIGNOR-252494
AKT	phosphorylation up-regulates →	TBC1D4 PThr642	phosphorylation down-regulates ⊣	TBC1D4	16880201	SIGNOR-148342

Regulator	Mechanism/Effect	Target	SIGNOR-ID
AKT2	phosphorylation → down-regulates activity	TBC1D4	SIGNOR-280179
AKT	phosphorylation down-regulates	TBC1D4	SIGNOR-99300
AKT1	phosphorylation down-regulates	TBC1D4	SIGNOR-252594
AKT	phosphorylation → unknown	TBC1D4	SIGNOR-245268
AKT1	phosphorylation → unknown	TBC1D4	SIGNOR-252494
AKT	phosphorylation → unknown	TBC1D4	SIGNOR-148342