| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | CTNND1 | Tyr280 | HRFHPEPyGLEDDQR | phosphorylation up-regulates activity | 11382764 | SIGNOR-246492 |
| SRC | CTNND1 | Tyr257 | APSRQDVyGPQPQVR | phosphorylation up-regulates activity | 11382764 | SIGNOR-246488 |
| SRC | CTNND1 | Tyr302 | DYGMMSDyGTARRTG | phosphorylation up-regulates activity | 11382764 | SIGNOR-246504 |
| PRKACA | CTNND1 | Ser879 | LIDRNQKsDKKPDRE | phosphorylation down-regulates | 22798526 | SIGNOR-198288 |
| SRC | CTNND1 | Tyr291 | DDQRSMGyDDLDYGM | phosphorylation up-regulates activity | 11382764 | SIGNOR-246496 |
| PTPRM | CTNND1 | – | dephosphorylation down-regulates quantity | 21998202 | SIGNOR-277042 | |
| PRKCE | CTNND1 | Ser268 | PQVRVGGsSVDLHRF | phosphorylation down-regulates | 23542175 | SIGNOR-201600 |
| PRKCA | CTNND1 | Ser879 | LIDRNQKsDKKPDRE | phosphorylation down-regulates activity | 22798526 | SIGNOR-278261 |
| PRKCE | CTNND1 | Ser268 | PQVRVGGsSVDLHRF | phosphorylation down-regulates | 21251911 | SIGNOR-171712 |
| CSF1R | CTNND1 | Tyr228 | YPGGSDNyGSLSRVT | phosphorylation up-regulates quantity by stabilization | 21049007 | SIGNOR-278928 |
| CSF1R | CTNND1 | Tyr904 | TKSLDNNySTPNERG | phosphorylation up-regulates quantity by stabilization | 21049007 | SIGNOR-278929 |
| SRC | CTNND1 | Tyr228 | YPGGSDNyGSLSRVT | phosphorylation up-regulates activity | 11382764 | SIGNOR-246484 |
| SRC | CTNND1 | Tyr296 | MGYDDLDyGMMSDYG | phosphorylation up-regulates activity | 11382764 | SIGNOR-246500 |
| EGFR | CTNND1 | Tyr228 | YPGGSDNyGSLSRVT | phosphorylation unknown | 14996911 | SIGNOR-251092 |
| CSNK1A1 | CTNND1 | Ser269 | QVRVGGSsVDLHRFH | phosphorylation up-regulates activity | 24412065 | SIGNOR-277893 |
| MAPK3 | CTNND1 | Thr906 | SLDNNYStPNERGDH | phosphorylation down-regulates activity | 32010791 | SIGNOR-277506 |
| SRC | CTNND1 | Tyr96 | QDHSHLLySTIPRMQ | phosphorylation up-regulates activity | 11382764 | SIGNOR-246508 |
| CSNK1E | CTNND1 | Ser268 | PQVRVGGsSVDLHRF | phosphorylation down-regulates | 3133391 | SIGNOR-24443 |
| GSK3B | CTNND1 | Thr310 | GTARRTGtPSDPRRR | phosphorylation unknown | 12885254 | SIGNOR-251235 |
| GSK3B | CTNND1 | Ser252 | MEGYRAPsRQDVYGP | phosphorylation unknown | 12885254 | SIGNOR-251234 |
| MAPK1 | CTNND1 | Thr906 | SLDNNYStPNERGDH | phosphorylation down-regulates activity | 32010791 | SIGNOR-277505 |
| SRC | CTNND1 | Tyr112 | PGQIVETyTEEDPEG | phosphorylation up-regulates activity | 11382764 | SIGNOR-246480 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | CTNND1 PTyr280 | phosphorylation up-regulates → | CTNND1 | 11382764 | SIGNOR-246492 |
| SRC | phosphorylation up-regulates → | CTNND1 PTyr257 | phosphorylation up-regulates → | CTNND1 | 11382764 | SIGNOR-246488 |
| SRC | phosphorylation up-regulates → | CTNND1 PTyr302 | phosphorylation up-regulates → | CTNND1 | 11382764 | SIGNOR-246504 |
| PRKACA | phosphorylation up-regulates → | CTNND1 PSer879 | phosphorylation down-regulates ⊣ | CTNND1 | 22798526 | SIGNOR-198288 |
| SRC | phosphorylation up-regulates → | CTNND1 PTyr291 | phosphorylation up-regulates → | CTNND1 | 11382764 | SIGNOR-246496 |
| PRKCE | phosphorylation up-regulates → | CTNND1 PSer268 | phosphorylation down-regulates ⊣ | CTNND1 | 23542175 | SIGNOR-201600 |
| PRKCA | phosphorylation up-regulates → | CTNND1 PSer879 | phosphorylation down-regulates ⊣ | CTNND1 | 22798526 | SIGNOR-278261 |
| PRKCE | phosphorylation up-regulates → | CTNND1 PSer268 | phosphorylation down-regulates ⊣ | CTNND1 | 21251911 | SIGNOR-171712 |
| CSF1R | phosphorylation up-regulates → | CTNND1 PTyr228 | phosphorylation up-regulates → | CTNND1 | 21049007 | SIGNOR-278928 |
| CSF1R | phosphorylation up-regulates → | CTNND1 PTyr904 | phosphorylation up-regulates → | CTNND1 | 21049007 | SIGNOR-278929 |
| SRC | phosphorylation up-regulates → | CTNND1 PTyr228 | phosphorylation up-regulates → | CTNND1 | 11382764 | SIGNOR-246484 |
| SRC | phosphorylation up-regulates → | CTNND1 PTyr296 | phosphorylation up-regulates → | CTNND1 | 11382764 | SIGNOR-246500 |
| EGFR | phosphorylation up-regulates → | CTNND1 PTyr228 | phosphorylation down-regulates ⊣ | CTNND1 | 14996911 | SIGNOR-251092 |
| CSNK1A1 | phosphorylation up-regulates → | CTNND1 PSer269 | phosphorylation up-regulates → | CTNND1 | 24412065 | SIGNOR-277893 |
| MAPK3 | phosphorylation up-regulates → | CTNND1 PThr906 | phosphorylation down-regulates ⊣ | CTNND1 | 32010791 | SIGNOR-277506 |
| SRC | phosphorylation up-regulates → | CTNND1 PTyr96 | phosphorylation up-regulates → | CTNND1 | 11382764 | SIGNOR-246508 |
| CSNK1E | phosphorylation up-regulates → | CTNND1 PSer268 | phosphorylation down-regulates ⊣ | CTNND1 | 3133391 | SIGNOR-24443 |
| GSK3B | phosphorylation up-regulates → | CTNND1 PThr310 | phosphorylation down-regulates ⊣ | CTNND1 | 12885254 | SIGNOR-251235 |
| GSK3B | phosphorylation up-regulates → | CTNND1 PSer252 | phosphorylation down-regulates ⊣ | CTNND1 | 12885254 | SIGNOR-251234 |
| MAPK1 | phosphorylation up-regulates → | CTNND1 PThr906 | phosphorylation down-regulates ⊣ | CTNND1 | 32010791 | SIGNOR-277505 |
| SRC | phosphorylation up-regulates → | CTNND1 PTyr112 | phosphorylation up-regulates → | CTNND1 | 11382764 | SIGNOR-246480 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → up-regulates activity | CTNND1 | SIGNOR-246492 |
| SRC | phosphorylation → up-regulates activity | CTNND1 | SIGNOR-246488 |
| SRC | phosphorylation → up-regulates activity | CTNND1 | SIGNOR-246504 |
| PRKACA | phosphorylation down-regulates | CTNND1 | SIGNOR-198288 |
| SRC | phosphorylation → up-regulates activity | CTNND1 | SIGNOR-246496 |
| PTPRM | dephosphorylation → down-regulates quantity | CTNND1 | SIGNOR-277042 |
| PRKCE | phosphorylation down-regulates | CTNND1 | SIGNOR-201600 |
| PRKCA | phosphorylation → down-regulates activity | CTNND1 | SIGNOR-278261 |
| PRKCE | phosphorylation down-regulates | CTNND1 | SIGNOR-171712 |
| CSF1R | phosphorylation → up-regulates quantity by stabilization | CTNND1 | SIGNOR-278928 |
| CSF1R | phosphorylation → up-regulates quantity by stabilization | CTNND1 | SIGNOR-278929 |
| SRC | phosphorylation → up-regulates activity | CTNND1 | SIGNOR-246484 |
| SRC | phosphorylation → up-regulates activity | CTNND1 | SIGNOR-246500 |
| EGFR | phosphorylation → unknown | CTNND1 | SIGNOR-251092 |
| CSNK1A1 | phosphorylation → up-regulates activity | CTNND1 | SIGNOR-277893 |
| MAPK3 | phosphorylation → down-regulates activity | CTNND1 | SIGNOR-277506 |
| SRC | phosphorylation → up-regulates activity | CTNND1 | SIGNOR-246508 |
| CSNK1E | phosphorylation down-regulates | CTNND1 | SIGNOR-24443 |
| GSK3B | phosphorylation → unknown | CTNND1 | SIGNOR-251235 |
| GSK3B | phosphorylation → unknown | CTNND1 | SIGNOR-251234 |
| MAPK1 | phosphorylation → down-regulates activity | CTNND1 | SIGNOR-277505 |
| SRC | phosphorylation → up-regulates activity | CTNND1 | SIGNOR-246480 |
