| Name | ROCK2 |
| ID | O75116 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 92-354 PROSITE-ProRule
AGC-kinase C-terminal 357-425 PROSITE-ProRule
REM-1 497-573 PROSITE-ProRule
RhoBD 979-1047 PROSITE-ProRule
PH 1150-1349 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ROCK2 | MYL12B | – | phosphorylation up-regulates activity | 25412762 | SIGNOR-279103 | |
| ROCK2 | PPP1R12A | Thr853 | PREKRRStGVSFWTQ | phosphorylation down-regulates activity | 12220642 | SIGNOR-249164 |
| ROCK2 | APP | Thr729 | MLKKKQYtSIHHGVV | phosphorylation up-regulates quantity | 24305806 | SIGNOR-280109 |
| ROCK2 | MYL9 | Ser20 | KRPQRATsNVFAMFD | phosphorylation up-regulates activity | 8702756 | SIGNOR-261719 |
| ROCK2 | MYL9 | Ser20 | KRPQRATsNVFAMFD | phosphorylation up-regulates activity | 8702756 | SIGNOR-261709 |
| ROCK2 | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates activity | 8702756 | SIGNOR-261708 |
| ROCK2 | MYL9 | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates activity | 8702756 | SIGNOR-261718 |
| ROCK2 | EP300 | – | phosphorylation up-regulates activity | 16574662 | SIGNOR-279482 | |
| ROCK2 | IRF4 | Ser447 | YHRSIRHsSIQE | phosphorylation up-regulates | 20697158 | SIGNOR-167467 |
| ROCK2 | IRF4 | Ser448 | HRSIRHSsIQE | phosphorylation up-regulates | 20697158 | SIGNOR-167471 |
| ROCK2 | DPYSL2 | Thr555 | DNIPRRTtQRIVAPP | phosphorylation up-regulates | 10818093 | SIGNOR-77543 |
| ROCK2 | PPP1R14A | Thr38 | QKRHARVtVKYDRRE | phosphorylation up-regulates activity | 32471307 | SIGNOR-90832 |
| ROCK2 | PPP1R14A | Thr38 | QKRHARVtVKYDRRE | phosphorylation up-regulates activity | 32471307 | SIGNOR-96696 |
| ROCK2 | SH3GL2 | Thr14 | KKQFHKAtQKVSEKV | phosphorylation down-regulates | 16164598 | SIGNOR-140466 |
| ROCK2 | LHX3 | – | phosphorylation up-regulates activity | 24071938 | SIGNOR-280110 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ROCK2 | phosphorylation up-regulates → | PPP1R12A PThr853 | phosphorylation down-regulates ⊣ | PPP1R12A | 12220642 | SIGNOR-249164 |
| ROCK2 | phosphorylation up-regulates → | APP PThr729 | phosphorylation up-regulates → | APP | 24305806 | SIGNOR-280109 |
| ROCK2 | phosphorylation up-regulates → | MYL9 PSer20 | phosphorylation up-regulates → | MYL9 | 8702756 | SIGNOR-261719 |
| ROCK2 | phosphorylation up-regulates → | MYL9 PSer20 | phosphorylation up-regulates → | MYL9 | 8702756 | SIGNOR-261709 |
| ROCK2 | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 8702756 | SIGNOR-261708 |
| ROCK2 | phosphorylation up-regulates → | MYL9 PThr19 | phosphorylation up-regulates → | MYL9 | 8702756 | SIGNOR-261718 |
| ROCK2 | phosphorylation up-regulates → | IRF4 PSer447 | phosphorylation up-regulates → | IRF4 | 20697158 | SIGNOR-167467 |
| ROCK2 | phosphorylation up-regulates → | IRF4 PSer448 | phosphorylation up-regulates → | IRF4 | 20697158 | SIGNOR-167471 |
| ROCK2 | phosphorylation up-regulates → | DPYSL2 PThr555 | phosphorylation up-regulates → | DPYSL2 | 10818093 | SIGNOR-77543 |
| ROCK2 | phosphorylation up-regulates → | PPP1R14A PThr38 | phosphorylation up-regulates → | PPP1R14A | 32471307 | SIGNOR-90832 |
| ROCK2 | phosphorylation up-regulates → | PPP1R14A PThr38 | phosphorylation up-regulates → | PPP1R14A | 32471307 | SIGNOR-96696 |
| ROCK2 | phosphorylation up-regulates → | SH3GL2 PThr14 | phosphorylation down-regulates ⊣ | SH3GL2 | 16164598 | SIGNOR-140466 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ROCK2 | phosphorylation → up-regulates activity | MYL12B | SIGNOR-279103 |
| ROCK2 | phosphorylation → down-regulates activity | PPP1R12A | SIGNOR-249164 |
| ROCK2 | phosphorylation → up-regulates quantity | APP | SIGNOR-280109 |
| ROCK2 | phosphorylation → up-regulates activity | MYL9 | SIGNOR-261719 |
| ROCK2 | phosphorylation → up-regulates activity | MYL9 | SIGNOR-261709 |
| ROCK2 | phosphorylation → up-regulates activity | MYL9 | SIGNOR-261708 |
| ROCK2 | phosphorylation → up-regulates activity | MYL9 | SIGNOR-261718 |
| ROCK2 | phosphorylation → up-regulates activity | EP300 | SIGNOR-279482 |
| ROCK2 | phosphorylation → up-regulates | IRF4 | SIGNOR-167467 |
| ROCK2 | phosphorylation → up-regulates | IRF4 | SIGNOR-167471 |
| ROCK2 | phosphorylation → up-regulates | DPYSL2 | SIGNOR-77543 |
| ROCK2 | phosphorylation → up-regulates activity | PPP1R14A | SIGNOR-90832 |
| ROCK2 | phosphorylation → up-regulates activity | PPP1R14A | SIGNOR-96696 |
| ROCK2 | phosphorylation down-regulates | SH3GL2 | SIGNOR-140466 |
| ROCK2 | phosphorylation → up-regulates activity | LHX3 | SIGNOR-280110 |