Summary

Name ROCK2
Full Name Rho-associated protein kinase 2
Synonyms Rho kinase 2, Rho-associated, coiled-coil-containing protein kinase 2, Rho-associated, coiled-coil-containing protein kinase II, ROCK-II, p164 ROCK-2 | KIAA0619
Primary ID O75116
Links - -
Type protein
Relations 20
Inhibitors Y-27632; N-(6-fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide
Function Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation MYL9 0.633
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IRF4 0.433
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SH3GL2 0.409
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PPP1R14A 0.43
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DPYSL2 0.397
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPP1R12A 0.778
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding ROCK2 0.294
Publications: 4 Organism: Chlorocebus Aethiops, Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ROCK2 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LPP 0.267
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Actin_cytoskeleton_reorganization 0.7
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ROCK2 0.8
Publications: 1 Organism: Homo Sapiens